4,6-diiodo-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidine

Base Information

• Chemical Name: 4,6-diiodo-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidine
• CAS No.: 1028271-85-3
• Molecular Formula: C₁₄H₁₄I₂N₂O
• Molecular Weight: 480.087
• Mol file: 1028271-85-3.mol

Synonyms:4,6-diiodo-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidine

Chemical Property of 4,6-diiodo-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,6-diiodo-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidine

There total 6 articles about 4,6-diiodo-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,6-dichloro-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidine (1027581-91-4) → 4,6-diiodo-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidine (1028271-85-3)

Guidance literature:

With hydrogen iodide; sodium iodide; In acetone; at 20 ℃;

DOI:10.1021/jm020049a

Reference yield:

(2-propenyl)propanedioic acid diethyl ester (2049-80-1) → 4,6-diiodo-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidine (1028271-85-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 58 percent / n-tributylamine; palladium acetate / acetonitrile / 4 h / Heating

2.1: 92 percent / H₂ / 10 percent Pd/C / ethyl acetate / 15 h / 760 Torr

3.1: sodium ethoxide / ethanol / 0 °C

3.2: ethanol / 20 °C

4.1: POCl₃ / Heating

5.1: NaI; aq. HI / acetone / 20 °C

With tributyl-amine; hydrogen iodide; hydrogen; sodium ethanolate; palladium diacetate; sodium iodide; trichlorophosphate; palladium on activated charcoal; In ethanol; ethyl acetate; acetone; acetonitrile;

DOI:10.1021/jm020049a

Reference yield:

para-iodoanisole (696-62-8) → 4,6-diiodo-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidine (1028271-85-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 58 percent / n-tributylamine; palladium acetate / acetonitrile / 4 h / Heating

2.1: 92 percent / H₂ / 10 percent Pd/C / ethyl acetate / 15 h / 760 Torr

3.1: sodium ethoxide / ethanol / 0 °C

3.2: ethanol / 20 °C

4.1: POCl₃ / Heating

5.1: NaI; aq. HI / acetone / 20 °C

With tributyl-amine; hydrogen iodide; hydrogen; sodium ethanolate; palladium diacetate; sodium iodide; trichlorophosphate; palladium on activated charcoal; In ethanol; ethyl acetate; acetone; acetonitrile;

DOI:10.1021/jm020049a

upstream raw materials:

4,6-dichloro-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidine

(2-propenyl)propanedioic acid diethyl ester

para-iodoanisole

diethyl 2-[3-(4-methoxyphenyl)propyl]malonate

Downstream raw materials:

6-iodo-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidin-4-ylamine