Technology Process of 4,6-dichloro-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidine
There total 5 articles about 4,6-dichloro-5-[3-(4-methoxy-phenyl)-propyl]-pyrimidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 58 percent / n-tributylamine; palladium acetate / acetonitrile / 4 h / Heating
2.1: 92 percent / H2 / 10 percent Pd/C / ethyl acetate / 15 h / 760 Torr
3.1: sodium ethoxide / ethanol / 0 °C
3.2: ethanol / 20 °C
4.1: POCl3 / Heating
With
tributyl-amine; hydrogen; sodium ethanolate; palladium diacetate; trichlorophosphate;
palladium on activated charcoal;
In
ethanol; ethyl acetate; acetonitrile;
DOI:10.1021/jm020049a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 58 percent / n-tributylamine; palladium acetate / acetonitrile / 4 h / Heating
2.1: 92 percent / H2 / 10 percent Pd/C / ethyl acetate / 15 h / 760 Torr
3.1: sodium ethoxide / ethanol / 0 °C
3.2: ethanol / 20 °C
4.1: POCl3 / Heating
With
tributyl-amine; hydrogen; sodium ethanolate; palladium diacetate; trichlorophosphate;
palladium on activated charcoal;
In
ethanol; ethyl acetate; acetonitrile;
DOI:10.1021/jm020049a
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 92 percent / H2 / 10 percent Pd/C / ethyl acetate / 15 h / 760 Torr
2.1: sodium ethoxide / ethanol / 0 °C
2.2: ethanol / 20 °C
3.1: POCl3 / Heating
With
hydrogen; sodium ethanolate; trichlorophosphate;
palladium on activated charcoal;
In
ethanol; ethyl acetate;
DOI:10.1021/jm020049a
