(2,6-difluorobenzyl) 2,2,2-trichloroacetimidate

Base Information

• Chemical Name: (2,6-difluorobenzyl) 2,2,2-trichloroacetimidate
• CAS No.: 367488-48-0
• Molecular Formula: C₉H₆Cl₃F₂NO
• Molecular Weight: 288.509
• Mol file: 367488-48-0.mol

Synonyms:(2,6-difluorobenzyl) 2,2,2-trichloroacetimidate

Chemical Property of (2,6-difluorobenzyl) 2,2,2-trichloroacetimidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,6-difluorobenzyl) 2,2,2-trichloroacetimidate

There total 2 articles about (2,6-difluorobenzyl) 2,2,2-trichloroacetimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,6-difluorobenzyl alcohol (19064-18-7) + trichloroacetonitrile (545-06-2) → (2,6-difluorobenzyl) 2,2,2-trichloroacetimidate (367488-48-0)

Guidance literature:

2,6-difluorobenzyl alcohol; With tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; at 0 ℃; for 0.0833333h;

trichloroacetonitrile; In dichloromethane; at 0 - 20 ℃; for 2.5h; Further stages.;

DOI:10.1021/jm001134q

Reference yield:

tert-butyl isocyanide (630-18-2) + 2,6-difluorobenzyl alcohol (19064-18-7) → (2,6-difluorobenzyl) 2,2,2-trichloroacetimidate (367488-48-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃;

DOI:10.3762/bjoc.14.207

Reference yield: 93.0%

L-mannaro-1,4:3,6-di-γ-lactone (214038-58-1) + (2,6-difluorobenzyl) 2,2,2-trichloroacetimidate (367488-48-0) → (3R,3aR,6R,6aR)-3,6-Bis-(2,6-difluoro-benzyloxy)-tetrahydro-furo[3,2-b]furan-2,5-dione (367488-53-7)

Guidance literature:

With trifluorormethanesulfonic acid; In 1,4-dioxane; for 6h;

DOI:10.1021/jm001134q

upstream raw materials:

2,6-difluorobenzyl alcohol

trichloroacetonitrile

tert-butyl isocyanide

Downstream raw materials:

(3R,3aR,6R,6aR)-3,6-Bis-(2,6-difluoro-benzyloxy)-tetrahydro-furo[3,2-b]furan-2,5-dione

Refernces

• 1、 Nakazato, Atsuro,Sakagami, Kazunari,Yasuhara, Akito,Ohta, Hiroshi,Yoshikawa, Ryoko,Itoh, Manabu,Nakamura, Masato,Chaki, Shigeyuki. "Synthesis, in vitro pharmacology, structure - Activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6- dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists". . p. 4570 - 4587. Retrieved 2007/10/03.