4-Chloro-6-(4-methoxy-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

Base Information

• Chemical Name: 4-Chloro-6-(4-methoxy-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide
• CAS No.: 78296-78-3
• Molecular Formula: C₁₄H₁₁ClN₆O₂
• Molecular Weight: 330.733
• Mol file: 78296-78-3.mol

Synonyms:4-Chloro-6-(4-methoxy-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

Chemical Property of 4-Chloro-6-(4-methoxy-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Chloro-6-(4-methoxy-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

There total 7 articles about 4-Chloro-6-(4-methoxy-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-aminotetrazole (4418-61-5) + 4-Chloro-6-(4-methoxy-phenyl)-pyridine-2-carbonyl chloride → 4-Chloro-6-(4-methoxy-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide (78296-78-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Yield given;

DOI:10.1021/jm00364a026

Reference yield:

4-chloro-2-(4-methoxyphenyl)pyridine (856851-28-0) → 4-Chloro-6-(4-methoxy-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide (78296-78-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 30percent aq. H₂O₂ / acetic acid / 20 h / 80 °C

2: 1.) Me₂SO₄ / 1.) 80-90 deg C, 2 h, 2.) dioxane, H₂O, RT, 30 min

3: 5 M aq. HCl / 11 h / Heating

4: SOCl₂ / 1 h / Heating

5: Et₃N / dimethylformamide / 2 h / 80 °C

With hydrogenchloride; thionyl chloride; dihydrogen peroxide; triethylamine; dimethyl sulfate; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00364a026

Reference yield:

ethyl 6-(4-methoxyphenyl)-4-oxo-4H-pyran-2-carboxylate (76781-68-5) → 4-Chloro-6-(4-methoxy-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide (78296-78-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 17percent ethanolic NH₃, 2.) concd. HCl / 1.) from 100 deg C to 110 deg C, 18 h, 2.) reflux, 18 h

2: SOCl₂ / 5 h / Heating

3: Et₃N / dimethylformamide / 2 h / 80 °C

With hydrogenchloride; thionyl chloride; ammonia; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00364a026

upstream raw materials:

5-aminotetrazole

4-chloro-2-(4-methoxyphenyl)pyridine

ethyl 6-(4-methoxyphenyl)-4-oxo-4H-pyran-2-carboxylate

4-Chloro-6-(4-methoxy-phenyl)-pyridine-2-carboxylic acid