5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(2,4,6-trimethylphenyl)isoxazole

Base Information

• Chemical Name: 5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(2,4,6-trimethylphenyl)isoxazole
• CAS No.: 374715-18-1
• Molecular Formula: C₁₉H₂₆BNO₃
• Molecular Weight: 327.231
• Mol file: 374715-18-1.mol

Synonyms:5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(2,4,6-trimethylphenyl)isoxazole

Chemical Property of 5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(2,4,6-trimethylphenyl)isoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(2,4,6-trimethylphenyl)isoxazole

There total 1 articles about 5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(2,4,6-trimethylphenyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

mesitylenecarbonitrile oxide (2904-57-6) + 4,4,5,5-tetramethyl-2-(prop-1-yn-1-yl)-1,3,2-dioxaborolane (347389-75-7) → 5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(2,4,6-trimethylphenyl)isoxazole (374715-18-1)

Guidance literature:

In diethyl ether; for 64h; Heating;

DOI:10.1039/b103319k DOI:10.1016/j.tet.2005.05.015

Reference yield: 78.0%

4-bromo-benzenesulfonic acid amide (701-34-8) + 5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(2,4,6-trimethylphenyl)isoxazole (374715-18-1) → 4-[5-methyl-3-(2,4,6-trimethylphenyl)-isoxazol-4-yl]-benzenesulfonamide

Guidance literature:

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 85 ℃; for 64h;

DOI:10.1016/j.tet.2005.05.015

Reference yield:

allyl bromide (106-95-6) + 5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(2,4,6-trimethylphenyl)isoxazole (374715-18-1) → 5-methyl-4-phenyl-3-(2,4,6-trimethylphenyl)isoxazole (374715-26-1)

Guidance literature:

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 85 ℃; for 64h;

DOI:10.1039/b103319k

upstream raw materials:

mesitylenecarbonitrile oxide

4,4,5,5-tetramethyl-2-(prop-1-yn-1-yl)-1,3,2-dioxaborolane

Downstream raw materials:

5-methyl-4-phenyl-3-(2,4,6-trimethylphenyl)isoxazole