(6R,13R)-2,9-dibenzyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole

Base Information

• Chemical Name: (6R,13R)-2,9-dibenzyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole
• CAS No.: 899789-25-4
• Molecular Formula: C₃₅H₃₂N₄O₂
• Molecular Weight: 540.665
• Mol file: 899789-25-4.mol

Synonyms:(6R,13R)-2,9-dibenzyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole

Chemical Property of (6R,13R)-2,9-dibenzyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R,13R)-2,9-dibenzyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole

There total 1 articles about (6R,13R)-2,9-dibenzyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(1S,5S)-bicyclo[3.3.1]nonane-2,6-dione bis[(1-benzyl-6-methyl-2-oxo-1,2-dihydro-4-pyridinyl)hydrazone] (899789-29-8) → (6R,13R)-2,9-dibenzyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole (899789-25-4)

Guidance literature:

In diphenylether; Heating;

DOI:10.1021/ja061160z

Reference yield: 83.0%

(6R,13R)-2,9-dibenzyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole (899789-25-4) + 1-bromo dodecane (112-29-8) → (-)-(6R,13R)-2,9-dibenzyl-5,12-didecyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole (899789-31-2)

Guidance literature:

(6R,13R)-2,9-dibenzyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole; With sodium hydride; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

1-bromo dodecane; With potassium iodide; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/ja061160z

Reference yield: 83.0%

(6R,13R)-2,9-dibenzyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole (899789-25-4) + Iododecane (2050-77-3) → (-)-(6R,13R)-2,9-dibenzyl-5,12-didecyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole (899789-31-2)

Guidance literature:

(6R,13R)-2,9-dibenzyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole; With sodium hydride; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Iododecane; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/ja061160z

upstream raw materials:

(1S,5S)-bicyclo[3.3.1]nonane-2,6-dione bis[(1-benzyl-6-methyl-2-oxo-1,2-dihydro-4-pyridinyl)hydrazone]

Downstream raw materials:

(-)-(6R,13R)-2,9-dibenzyl-5,12-didecyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole