(1S,5S)-bicyclo[3.3.1]nonane-2,6-dione bis[(1-benzyl-6-methyl-2-oxo-1,2-dihydro-4-pyridinyl)hydrazone]

Base Information

• Chemical Name: (1S,5S)-bicyclo[3.3.1]nonane-2,6-dione bis[(1-benzyl-6-methyl-2-oxo-1,2-dihydro-4-pyridinyl)hydrazone]
• CAS No.: 899789-29-8
• Molecular Formula: C₃₅H₃₈N₆O₂
• Molecular Weight: 574.726
• Mol file: 899789-29-8.mol

Synonyms:(1S,5S)-bicyclo[3.3.1]nonane-2,6-dione bis[(1-benzyl-6-methyl-2-oxo-1,2-dihydro-4-pyridinyl)hydrazone]

Chemical Property of (1S,5S)-bicyclo[3.3.1]nonane-2,6-dione bis[(1-benzyl-6-methyl-2-oxo-1,2-dihydro-4-pyridinyl)hydrazone]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,5S)-bicyclo[3.3.1]nonane-2,6-dione bis[(1-benzyl-6-methyl-2-oxo-1,2-dihydro-4-pyridinyl)hydrazone]

There total 5 articles about (1S,5S)-bicyclo[3.3.1]nonane-2,6-dione bis[(1-benzyl-6-methyl-2-oxo-1,2-dihydro-4-pyridinyl)hydrazone] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-benzyl-4-hydrazino-6-methyl-2(1H)-pyridinone (899789-26-5) + (S,S)-bicyclo[3.3.1]nonane-2,6-dione (36415-87-9) → (1S,5S)-bicyclo[3.3.1]nonane-2,6-dione bis[(1-benzyl-6-methyl-2-oxo-1,2-dihydro-4-pyridinyl)hydrazone] (899789-29-8)

Guidance literature:

In methanol; for 5h; Heating;

DOI:10.1021/ja061160z

Reference yield:

4-hydroxy-6-methyl-2-pyron (675-10-5) → (1S,5S)-bicyclo[3.3.1]nonane-2,6-dione bis[(1-benzyl-6-methyl-2-oxo-1,2-dihydro-4-pyridinyl)hydrazone] (899789-29-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 56 percent / H₂O / 16 h / Heating

2: 27 percent / POCl₃ / 0.67 h / 80 °C

3: 81 percent / hydrazine monohydrate / methanol / 30 h / Heating

4: 95 percent / methanol / 5 h / Heating

With hydrazine hydrate; trichlorophosphate; In methanol; water;

DOI:10.1021/ja061160z

Reference yield:

1-benzyl-6-methyl-1,2,3,4-tetrahydropyridine-2,4-dione (33524-79-7) → (1S,5S)-bicyclo[3.3.1]nonane-2,6-dione bis[(1-benzyl-6-methyl-2-oxo-1,2-dihydro-4-pyridinyl)hydrazone] (899789-29-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 27 percent / POCl₃ / 0.67 h / 80 °C

2: 81 percent / hydrazine monohydrate / methanol / 30 h / Heating

3: 95 percent / methanol / 5 h / Heating

With hydrazine hydrate; trichlorophosphate; In methanol;

DOI:10.1021/ja061160z

upstream raw materials:

1-benzyl-4-hydrazino-6-methyl-2(1H)-pyridinone

(S,S)-bicyclo[3.3.1]nonane-2,6-dione

1-benzyl-4-chloro-6-methyl-2(1H)-pyridinone

4-hydroxy-6-methyl-2-pyron

Downstream raw materials:

(6R,13R)-2,9-dibenzyl-2,9-diaza-3,10-dimethyl-1,8-dioxo-2,5,6,7,9,12,13,14-octahydro-6,13-methanocycloocta[1,2-b:5,6-b']diindole