7-(N^α-Z-L-Argininamido)-4-(trifluoromethyl)-coumarin Hydrochloride

Base Information

• Chemical Name: 7-(N^α-Z-L-Argininamido)-4-(trifluoromethyl)-coumarin Hydrochloride
• CAS No.: 73496-38-5
• Molecular Formula: C₂₄H₂₄F₃N₅O₅*ClH
• Molecular Weight: 555.941
• Mol file: 73496-38-5.mol

Synonyms:7-(N^α-Z-L-Argininamido)-4-(trifluoromethyl)-coumarin Hydrochloride

Chemical Property of 7-(N^α-Z-L-Argininamido)-4-(trifluoromethyl)-coumarin Hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(N^α-Z-L-Argininamido)-4-(trifluoromethyl)-coumarin Hydrochloride

There total 1 articles about 7-(N^α-Z-L-Argininamido)-4-(trifluoromethyl)-coumarin Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Arg-OH (1234-35-1) + Coumarin 151 (53518-15-3) → 7-(Nα-Z-L-Argininamido)-4-(trifluoromethyl)-coumarin Hydrochloride (73496-38-5)

Guidance literature:

With isobutyl chloroformate; Multistep reaction;

DOI:10.1021/jo01300a003

Reference yield:

CbzGlyGly (2566-19-0) + 7-(Nα-Z-L-Argininamido)-4-(trifluoromethyl)-coumarin Hydrochloride (73496-38-5) → 7-(Nα-Z-Glycylglycyl-L-argininamido)-4-(trifluoromethyl)coumarin Dihydrochloride (73389-51-2)

Guidance literature:

With 4-methyl-morpholine; palladium on activated charcoal; hydrogen; isobutyl chloroformate; Yield given. Multistep reaction;

DOI:10.1021/jo01300a003

Reference yield:

7-(Nα-Z-L-Argininamido)-4-(trifluoromethyl)-coumarin Hydrochloride (73496-38-5) → 7-(Nα-Z-Glycylglycyl-L-argininamido)-4-(trifluoromethyl)coumarin Dihydrochloride (73389-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / HBr / acetic acid / 0.5 h / Ambient temperature

2: 23 percent / triethylamine / pyridine / 72 h / Ambient temperature

With hydrogen bromide; triethylamine; In pyridine; acetic acid;

DOI:10.1021/jo01300a003

upstream raw materials:

Z-Arg-OH

Coumarin 151

Downstream raw materials:

7-(N^α-Z-Glycylglycyl-L-argininamido)-4-(trifluoromethyl)coumarin Dihydrochloride