7-Amino-4-(trifluoromethyl)coumarin

Base Information

Chemical Name:7-Amino-4-(trifluoromethyl)coumarin
CAS No.:53518-15-3
Molecular Formula:C10H6F3NO2
Molecular Weight:229.158
Hs Code.:29322090
European Community (EC) Number:258-599-1
NSC Number:337981
UNII:P5QQ8K4F5Q
DSSTox Substance ID:DTXSID0068862
Nikkaji Number:J236.240F
Wikidata:Q27122739
ChEMBL ID:CHEMBL1301731
Mol file:53518-15-3.mol

Synonyms:7-amino-4-trifluoromethylcoumarin;7-ATFMC;ATFMC cpd

Suppliers and Price of 7-Amino-4-(trifluoromethyl)coumarin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7-Amino-4-(trifluoromethyl)coumarin
1g
$ 165.00

TRC
7-Amino-4-(trifluoromethyl)coumarin
250mg
$ 85.00

SynQuest Laboratories
7-Amino-4-(trifluoromethyl)coumarin 99%
1 g
$ 35.00

SynQuest Laboratories
7-Amino-4-(trifluoromethyl)coumarin 99%
5 g
$ 125.00

Sigma-Aldrich
7-Amino-4-(trifluoromethyl)coumarin ≥99%
1g
$ 152.00

Sigma-Aldrich
7-Amino-4-(trifluoromethyl)coumarin ≥99%
250mg
$ 46.20

Oakwood
7-Amino-4-(trifluoromethyl)coumarin
1g
$ 45.00

Oakwood
7-Amino-4-(trifluoromethyl)coumarin
250mg
$ 23.00

Oakwood
7-Amino-4-(trifluoromethyl)coumarin
5g
$ 175.00

Matrix Scientific
7-Amino-4-(trifluoromethyl)coumarin 99%
1g
$ 30.00

Total 43 raw suppliers

Chemical Property of 7-Amino-4-(trifluoromethyl)coumarin

Chemical Property:

Appearance/Colour:yellow powder
Melting Point:221-222 ºC
Boiling Point:314.6°Cat760mmHg
PKA:1.12±0.20(Predicted)
Flash Point:144.1°C
PSA：56.23000
Density:1.523g/cm³
LogP:2.97520
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Water Solubility.:Soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water.
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:0
Exact Mass:229.03506292
Heavy Atom Count:16
Complexity:337

Purity/Quality:

97% ^*data from raw suppliers

7-Amino-4-(trifluoromethyl)coumarin ^*data from reagent suppliers

Safty Information:

Pictogram(s): XnXi
Hazard Codes:Xi,Xn
Statements: 36/37/38-20/21/22
Safety Statements: 26-36-37/39

MSDS Files:: SDS file from LookChem

Useful:

Chemical Classes:Dyes -> Coumarin Dyes
Canonical SMILES:C1=CC2=C(C=C1N)OC(=O)C=C2C(F)(F)F
Uses Coumarin 151 is used to prepare peptidase substrates and for the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids. 7-Amino-4-(trifluoromethyl)coumarin is used in the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids. It is suitable as laser dye.

Technology Process of 7-Amino-4-(trifluoromethyl)coumarin

There total 27 articles about 7-Amino-4-(trifluoromethyl)coumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 372-31-6
ethyl 4,4,4-trifluoroacetoacetate

: 591-27-5
m-Hydroxyaniline

: 53518-15-3
Coumarin 151

Guidance literature:: With magnesium bis(trifluoromethane solfonyl)imide; In neat (no solvent); at 80 ℃; for 0.416667h;
DOI:10.1007/s00706-012-0823-4

Reference yield: 85.0%

: 372-31-6
ethyl 4,4,4-trifluoroacetoacetate

: 591-27-5
m-Hydroxyaniline

: 73496-29-4
7-hydroxy-4-(trifluoromethyl)-2(1H)-quinolinone

: 53518-15-3
Coumarin 151

Guidance literature:: indium(III) chloride; at 65 ℃; for 0.5h;
DOI:10.1016/S0040-4039(02)02266-9

Reference yield: 46.0%

: 63450-46-4
7-(Carbethoxyamido)-4-(trifluoromethylcoumarin)

: 53518-15-3
Coumarin 151

Guidance literature:: 7-(Carbethoxyamido)-4-(trifluoromethylcoumarin); With sulfuric acid; acetic acid; for 4h; Reflux;

With sodium hydroxide; In water; Cooling;
DOI:10.1016/j.bmc.2011.11.016