(1S)-[3-oxo-3-phenyl-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester

Base Information

• Chemical Name: (1S)-[3-oxo-3-phenyl-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester
• CAS No.: 714959-64-5
• Molecular Formula: C₁₆H₂₁Cl₃NO₆P
• Molecular Weight: 460.679
• Mol file: 714959-64-5.mol

Synonyms:(1S)-[3-oxo-3-phenyl-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester

Chemical Property of (1S)-[3-oxo-3-phenyl-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S)-[3-oxo-3-phenyl-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester

There total 6 articles about (1S)-[3-oxo-3-phenyl-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-styrenyloxytrimethylsilane (13735-81-4) + {[(E)-2,2,2-Trichloro-ethoxycarbonylimino]-methyl}-phosphonic acid diethyl ester → (1S)-[3-oxo-3-phenyl-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester (714959-64-5)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; C₃₈H₃₂CuF₆N₂O₄S₂; In dichloromethane; at 0 ℃; for 9h; Product distribution / selectivity; Molecular sieve 3A;

Reference yield:

1-styrenyloxytrimethylsilane (13735-81-4) + {[(E)-2,2,2-Trichloro-ethoxycarbonylimino]-methyl}-phosphonic acid diethyl ester → (1S)-[3-oxo-3-phenyl-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester (714959-64-5) + (1R)-[3-oxo-3-phenyl-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester

Guidance literature:

With (1R,2R)-N,N’-bis(naphthalen-1-ylmethyl)-1,2-diphenylethane-1,2-diamine; 1,1,1,3',3',3'-hexafluoro-propanol; 3 A molecular sieve; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; for 9h; Title compound not separated from byproducts;

DOI:10.1021/ja048791i

Reference yield:

[bromo-(2,2,2-trichloroethoxycarbonylamino)methyl]phosphonic acid diethyl ester (108217-08-9) → (1S)-[3-oxo-3-phenyl-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester (714959-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidinomethylpolystyrene; 4A molecular sieves / CH₂Cl₂ / 0.33 h / 20 °C

2: hexafluoroisopropyl alcohol; (R,R)-N,N'-(1-naphthylmethyl)-1,2-diphenylethane-1,2-diamine; 3A molecular sieves / Cu(OTf)2 / CH₂Cl₂ / 9 h

With (1R,2R)-N,N’-bis(naphthalen-1-ylmethyl)-1,2-diphenylethane-1,2-diamine; piperidinomethylpolystyrene; 1,1,1,3',3',3'-hexafluoro-propanol; 3 A molecular sieve; 4 A molecular sieve; copper(II) bis(trifluoromethanesulfonate); In dichloromethane;

DOI:10.1021/ja048791i

upstream raw materials:

1-styrenyloxytrimethylsilane

N-(1-phenylethenyl)benzamide

(1-phenylvinyl)carbamic acid benzyl ester

benzonitrile

Downstream raw materials:

((S)-1-Amino-3-oxo-3-phenyl-propyl)-phosphonic acid diethyl ester