ethyl (3'-(2-((4-methoxyphenyl)(methyl)amino)-2-oxoethyl)-1,1'-dimethyl-2,2'-dioxo-3,3'-biindolin-3-yl)acetate

Base Information

Chemical Name:ethyl (3'-(2-((4-methoxyphenyl)(methyl)amino)-2-oxoethyl)-1,1'-dimethyl-2,2'-dioxo-3,3'-biindolin-3-yl)acetate
CAS No.:1360873-40-0
Molecular Formula:C₃₂H₃₃N₃O₆
Molecular Weight:555.631
Hs Code.:

Synonyms:ethyl (3'-(2-((4-methoxyphenyl)(methyl)amino)-2-oxoethyl)-1,1'-dimethyl-2,2'-dioxo-3,3'-biindolin-3-yl)acetate

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Chemical Property of ethyl (3'-(2-((4-methoxyphenyl)(methyl)amino)-2-oxoethyl)-1,1'-dimethyl-2,2'-dioxo-3,3'-biindolin-3-yl)acetate

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Technology Process of ethyl (3'-(2-((4-methoxyphenyl)(methyl)amino)-2-oxoethyl)-1,1'-dimethyl-2,2'-dioxo-3,3'-biindolin-3-yl)acetate

There total 6 articles about ethyl (3'-(2-((4-methoxyphenyl)(methyl)amino)-2-oxoethyl)-1,1'-dimethyl-2,2'-dioxo-3,3'-biindolin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1360873-39-7
C₂₈H₂₇N₃O₄

: 105-36-2
ethyl bromoacetate

: 1360873-40-0
ethyl (3'-(2-((4-methoxyphenyl)(methyl)amino)-2-oxoethyl)-1,1'-dimethyl-2,2'-dioxo-3,3'-biindolin-3-yl)acetate

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In water; toluene; at 20 ℃; optical yield given as %ee;
DOI:10.1002/anie.201107079

Reference yield:

: 1360873-35-3
C₂₇H₂₄N₂O₃

: 1360873-40-0
ethyl (3'-(2-((4-methoxyphenyl)(methyl)amino)-2-oxoethyl)-1,1'-dimethyl-2,2'-dioxo-3,3'-biindolin-3-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine; hydroxylamine hydrochloride / ethanol / 48 h / 20 °C

2: toluene-4-sulfonic acid / ethanol / 48 h / 20 °C

3: mercury dichloride / acetonitrile / 2 h / 80 °C / Inert atmosphere

4: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

5: hydrogenchloride; acetic acid; dimethyl sulfoxide / water / 3 h / 20 °C

6: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water; toluene / 20 °C

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; potassium tert-butylate; tetra(n-butyl)ammonium hydrogensulfate; toluene-4-sulfonic acid; acetic acid; dimethyl sulfoxide; mercury dichloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; toluene; acetonitrile; 3: Beckmann rearrangement;
DOI:10.1002/anie.201107079

Reference yield:

: 1360873-36-4
C₂₇H₂₅N₃O₃

: 1360873-40-0
ethyl (3'-(2-((4-methoxyphenyl)(methyl)amino)-2-oxoethyl)-1,1'-dimethyl-2,2'-dioxo-3,3'-biindolin-3-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / ethanol / 48 h / 20 °C

2: mercury dichloride / acetonitrile / 2 h / 80 °C / Inert atmosphere

3: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

4: hydrogenchloride; acetic acid; dimethyl sulfoxide / water / 3 h / 20 °C

5: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water; toluene / 20 °C

With hydrogenchloride; potassium tert-butylate; tetra(n-butyl)ammonium hydrogensulfate; toluene-4-sulfonic acid; acetic acid; dimethyl sulfoxide; mercury dichloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; toluene; acetonitrile; 2: Beckmann rearrangement;
DOI:10.1002/anie.201107079