6-Cyano-4-fluoro-2,2-dimethyl-3-oxo-chroman-4-carboxylic acid phenylamide

Base Information

Chemical Name:6-Cyano-4-fluoro-2,2-dimethyl-3-oxo-chroman-4-carboxylic acid phenylamide
CAS No.:135144-44-4
Molecular Formula:C₁₉H₁₅FN₂O₃
Molecular Weight:338.338
Hs Code.:

Synonyms:6-Cyano-4-fluoro-2,2-dimethyl-3-oxo-chroman-4-carboxylic acid phenylamide

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Chemical Property of 6-Cyano-4-fluoro-2,2-dimethyl-3-oxo-chroman-4-carboxylic acid phenylamide

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Technology Process of 6-Cyano-4-fluoro-2,2-dimethyl-3-oxo-chroman-4-carboxylic acid phenylamide

There total 3 articles about 6-Cyano-4-fluoro-2,2-dimethyl-3-oxo-chroman-4-carboxylic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 134148-64-4
N-phenyl-6-cyano-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-carboxamide

: 135144-44-4
6-Cyano-4-fluoro-2,2-dimethyl-3-oxo-chroman-4-carboxylic acid phenylamide

: C₃₈H₂₈N₄O₅

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1021/jm00112a037

Reference yield:

: 129718-00-9
6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-one

: 135144-44-4
6-Cyano-4-fluoro-2,2-dimethyl-3-oxo-chroman-4-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) KO-t-Bu / 1.) THF, RT, 0.75 h, 2.) THF, 3 h

2: 5 percent / diethylamidosulfur trifluoride (DAST) / CH₂Cl₂ / 24 h / Ambient temperature

With diethylamino-sulfur trifluoride; potassium tert-butylate; In dichloromethane;
DOI:10.1021/jm00112a037

Reference yield:

: 103-71-9
phenyl isocyanate

: 135144-44-4
6-Cyano-4-fluoro-2,2-dimethyl-3-oxo-chroman-4-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) KO-t-Bu / 1.) THF, RT, 0.75 h, 2.) THF, 3 h

2: 5 percent / diethylamidosulfur trifluoride (DAST) / CH₂Cl₂ / 24 h / Ambient temperature

With diethylamino-sulfur trifluoride; potassium tert-butylate; In dichloromethane;
DOI:10.1021/jm00112a037