Technology Process of (1-Benzyl-1H-benzoimidazol-2-yl)-isopropyl-(1-phenethyl-piperidin-4-yl)-amine
There total 12 articles about (1-Benzyl-1H-benzoimidazol-2-yl)-isopropyl-(1-phenethyl-piperidin-4-yl)-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 95 percent / H2 / 10 percent Pd/C / methanol / 760 Torr / Ambient temperature
2: 84 percent / tetrahydrofuran; ethanol / 25 °C
3: 98.4 percent / H2, ammonia / 5 percent Pd/C / methanol / 760 Torr / Ambient temperature
4: 18 percent / mercury oxide, sulfur / ethanol / 2 h / Heating
5: 1.) sodium hydride / 1.) dimethyl sulfoxide, benzene, 30 min, 2.) dimethyl sulfoxide, benzene, RT, overnight
6: 1.) sodium hydride / 1.) dimethyl sulfoxide, benzene, 30 min, 2.) dimethyl sulfoxide, benzene, RT, overnight
With
ammonia; hydrogen; sodium hydride; sulfur; mercury(II) oxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00150a029
- Guidance literature:
-
Multi-step reaction with 7 steps
1: tetrahydrofuran / 25 °C
2: H2, NH3 / 10 percent Pd/C / methanol / 760 Torr / Ambient temperature
3: HgO/S
4: 48 percent aq. HBr / 2 h / 120 °C
5: Na2CO3 / dimethylformamide / 70 °C
6: 1.) sodium hydride / 1.) dimethyl sulfoxide, benzene, 30 min, 2.) dimethyl sulfoxide, benzene, RT, overnight
7: 1.) sodium hydride / 1.) dimethyl sulfoxide, benzene, 30 min, 2.) dimethyl sulfoxide, benzene, RT, overnight
With
ammonia; hydrogen bromide; hydrogen; sodium hydride; sodium carbonate; sulfur; mercury(II) oxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 84 percent / tetrahydrofuran; ethanol / 25 °C
2: 98.4 percent / H2, ammonia / 5 percent Pd/C / methanol / 760 Torr / Ambient temperature
3: 18 percent / mercury oxide, sulfur / ethanol / 2 h / Heating
4: 1.) sodium hydride / 1.) dimethyl sulfoxide, benzene, 30 min, 2.) dimethyl sulfoxide, benzene, RT, overnight
5: 1.) sodium hydride / 1.) dimethyl sulfoxide, benzene, 30 min, 2.) dimethyl sulfoxide, benzene, RT, overnight
With
ammonia; hydrogen; sodium hydride; sulfur; mercury(II) oxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00150a029
