Phenmetrazine hydrochloride

Base Information

• Chemical Name: Phenmetrazine hydrochloride
• CAS No.: 1707-14-8
• Molecular Formula: C11H15 N O . Cl H
• Molecular Weight: 213.707
• Hs Code.: 2934999090
• European Community (EC) Number: 216-950-6
• NSC Number: 405728
• DSSTox Substance ID: DTXSID0047822
• Wikidata: Q27107702
• NCI Thesaurus Code: C66373
• Metabolomics Workbench ID: 68002
• ChEMBL ID: CHEMBL1200483
• Mol file: 1707-14-8.mol

Synonyms:Defenmetrazin;Fenmetrazin;Hydrochloride, Phenmetrazine;Oxazimedrine;Phenmetraline;Phenmetrazine;Phenmetrazine Hydrochloride;Preludin

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Chemical Property of Phenmetrazine hydrochloride

Chemical Property:

• Vapor Pressure: 0.00284mmHg at 25°C
• Melting Point: 175-177°C
• Boiling Point: 285.2°Cat760mmHg
• Flash Point: 112.7°C
• PSA: 21.26000
• Density: g/cm³
• LogP: 2.86680
• Storage Temp.: Controlled Substance, -20°C Freezer
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 213.0920418
• Heavy Atom Count: 14
• Complexity: 154

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C(OCCN1)C2=CC=CC=C2.Cl
• Uses: Anorexic. Controlled substance (stimulant).
• Therapeutic Function: Antiobesity

Technology Process of Phenmetrazine hydrochloride

There total 4 articles about Phenmetrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phendimetrazine (21784-30-5) → phenmetrazine hydrochloride (1707-14-8)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 2 h

2: 1) aq. H₂SO₄, 2) HCl / 1) heating, 3 h, 2) ether

With hydrogenchloride; sulfuric acid; In benzene;

DOI:10.1002/(SICI)1521-4184(199811)331:11<342::AID-ARDP342>3.0.CO;2-6

Reference yield:

3-Methyl-2-phenyl-morpholine-4-carboxylic acid ethyl ester (127634-96-2) → phenmetrazine hydrochloride (1707-14-8)

Guidance literature:

With hydrogenchloride; sulfuric acid; Multistep reaction; 1) heating, 3 h, 2) ether;

DOI:10.1002/(SICI)1521-4184(199811)331:11<342::AID-ARDP342>3.0.CO;2-6

Reference yield:

→ phenmetrazine hydrochloride (1707-14-8)

Guidance literature:

upstream raw materials:

3-Methyl-2-phenyl-morpholine-4-carboxylic acid ethyl ester

phendimetrazine

Downstream raw materials:

2-methyl-3-(3-methyl-2-phenyl-morpholin-4-yl)-1-phenyl-propan-1-one

2-methyl-3-(3-methyl-2-phenyl-morpholin-4-yl)-1-phenyl-propan-1-ol

3-methyl-2-phenyl-morpholine-4-carboxylic acid amide

2-methyl-3-(3-methyl-2-phenyl-morpholin-4-yl)-1-phenoxycarbonyloxy-1-phenyl-propane

Refernces