4,4,6-Trimethyl-2-methylsulfanyl-1-(2-nitro-phenyl)-1,4-dihydro-pyrimidine

Base Information

Chemical Name:4,4,6-Trimethyl-2-methylsulfanyl-1-(2-nitro-phenyl)-1,4-dihydro-pyrimidine
CAS No.:85311-48-4
Molecular Formula:C₁₄H₁₇N₃O₂S
Molecular Weight:291.374
Hs Code.:

Synonyms:4,4,6-Trimethyl-2-methylsulfanyl-1-(2-nitro-phenyl)-1,4-dihydro-pyrimidine

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Chemical Property of 4,4,6-Trimethyl-2-methylsulfanyl-1-(2-nitro-phenyl)-1,4-dihydro-pyrimidine

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Technology Process of 4,4,6-Trimethyl-2-methylsulfanyl-1-(2-nitro-phenyl)-1,4-dihydro-pyrimidine

There total 3 articles about 4,4,6-Trimethyl-2-methylsulfanyl-1-(2-nitro-phenyl)-1,4-dihydro-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 50403-73-1
4,4,6-trimethyl-1-(2-nitrophenyl)-1,4-dihydropyrimidine-2(3H)-thione

: 74-88-4
methyl iodide

: 85311-48-4
4,4,6-Trimethyl-2-methylsulfanyl-1-(2-nitro-phenyl)-1,4-dihydro-pyrimidine

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In benzene; for 2h; Ambient temperature;
DOI:10.1055/s-1982-30073

Reference yield:

: 141-79-7
4-methyl-pent-3-en-2-one

: 85311-48-4
4,4,6-Trimethyl-2-methylsulfanyl-1-(2-nitro-phenyl)-1,4-dihydro-pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / conc. HCl / H₂O / 1.) 25 deg C, 0.5 h, 2.) reflux, 3 h

2: 94 percent / 50percent aq. NaOH / tetrabutylammonium hydrogen sulphate / benzene / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In water; benzene;
DOI:10.1055/s-1982-30073

Reference yield:

: 88-74-4
2-nitro-aniline

: 85311-48-4
4,4,6-Trimethyl-2-methylsulfanyl-1-(2-nitro-phenyl)-1,4-dihydro-pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / conc. HCl / H₂O / 1.) 25 deg C, 0.5 h, 2.) reflux, 3 h

2: 94 percent / 50percent aq. NaOH / tetrabutylammonium hydrogen sulphate / benzene / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In water; benzene;
DOI:10.1055/s-1982-30073