(E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phenethyloxy-pyridin-2-yl]-acrylic acid methyl ester

Base Information

Chemical Name:(E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phenethyloxy-pyridin-2-yl]-acrylic acid methyl ester
CAS No.:170569-20-7
Molecular Formula:C₂₄H₂₁Cl₂NO₃S
Molecular Weight:474.408
Hs Code.:

Synonyms:(E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phenethyloxy-pyridin-2-yl]-acrylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phenethyloxy-pyridin-2-yl]-acrylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of (E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phenethyloxy-pyridin-2-yl]-acrylic acid methyl ester

There total 7 articles about (E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phenethyloxy-pyridin-2-yl]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 24966-39-0
2,6-dichlorothiophenol

: (E)-3-(6-Chloromethyl-3-phenethyloxy-pyridin-2-yl)-acrylic acid methyl ester; hydrochloride

: 170569-20-7
(E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phenethyloxy-pyridin-2-yl]-acrylic acid methyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 50 ℃; for 1h;
DOI:10.1021/jm960248s

Reference yield:

: 66497-42-5
3-hydroxy-6-methylpicolinaldehyde

: 170569-20-7
(E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phenethyloxy-pyridin-2-yl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / toluene / 0.5 h / 50 °C

2: 53 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 1.25 h / 0 - 20 °C

3: MCPBA / CH₂Cl₂ / 18 h / Ambient temperature

4: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature

5: SOCl₂ / toluene / 1 h

6: 87 percent / DBU / acetonitrile / 1 h / 50 °C

With thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic anhydride; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm960248s

Reference yield:

: 60-12-8
2-phenylethanol

: 170569-20-7
(E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phenethyloxy-pyridin-2-yl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 53 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 1.25 h / 0 - 20 °C

2: MCPBA / CH₂Cl₂ / 18 h / Ambient temperature

3: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature

4: SOCl₂ / toluene / 1 h

5: 87 percent / DBU / acetonitrile / 1 h / 50 °C

With thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic anhydride; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm960248s