4-{4-[5-(benzyloxy)pyridin-3-yl]-9H-carbazol-9-yl}-2-fluorobenzonitrile

Base Information

Chemical Name:4-{4-[5-(benzyloxy)pyridin-3-yl]-9H-carbazol-9-yl}-2-fluorobenzonitrile
CAS No.:1190423-63-2
Molecular Formula:C₃₁H₂₀FN₃O
Molecular Weight:469.518
Hs Code.:

Synonyms:4-{4-[5-(benzyloxy)pyridin-3-yl]-9H-carbazol-9-yl}-2-fluorobenzonitrile

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Chemical Property of 4-{4-[5-(benzyloxy)pyridin-3-yl]-9H-carbazol-9-yl}-2-fluorobenzonitrile

Chemical Property:

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Technology Process of 4-{4-[5-(benzyloxy)pyridin-3-yl]-9H-carbazol-9-yl}-2-fluorobenzonitrile

There total 5 articles about 4-{4-[5-(benzyloxy)pyridin-3-yl]-9H-carbazol-9-yl}-2-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190423-62-1
4-[5-(benzyloxy)pyridin-3-yl]-9H-carbazole

: 105942-08-3
4-bromo-6-fluorobenzonitrile

: 1190423-63-2
4-{4-[5-(benzyloxy)pyridin-3-yl]-9H-carbazol-9-yl}-2-fluorobenzonitrile

Guidance literature:: With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 2.5h; Reflux; Inert atmosphere;

Reference yield:

: 130722-95-1
3-(benzyloxy)-5-bromopyridine

: 1190423-63-2
4-{4-[5-(benzyloxy)pyridin-3-yl]-9H-carbazol-9-yl}-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 3 h / -70 °C / Inert atmosphere

1.2: -20 °C / Inert atmosphere

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 5 h / Reflux; Inert atmosphere

3.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2.5 h / Reflux; Inert atmosphere

With n-butyllithium; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; hexane; water; toluene;

Reference yield:

: 52602-39-8
9H-carbazol-4-ol

: 1190423-63-2
4-{4-[5-(benzyloxy)pyridin-3-yl]-9H-carbazol-9-yl}-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 5 h / Reflux; Inert atmosphere

3: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2.5 h / Reflux; Inert atmosphere

With caesium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water;