4-(1H-benzimidazol-2-yl)-1-(3-chlorophenyl)pyrrolidin-2-one

Base Information

• Chemical Name: 4-(1H-benzimidazol-2-yl)-1-(3-chlorophenyl)pyrrolidin-2-one
• CAS No.: 491874-28-3
• Molecular Formula: C₁₇H₁₄ClN₃O
• Molecular Weight: 311.771
• Mol file: 491874-28-3.mol

Synonyms:4-(1H-benzimidazol-2-yl)-1-(3-chlorophenyl)pyrrolidin-2-one

Chemical Property of 4-(1H-benzimidazol-2-yl)-1-(3-chlorophenyl)pyrrolidin-2-one

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Technology Process of 4-(1H-benzimidazol-2-yl)-1-(3-chlorophenyl)pyrrolidin-2-one

There total 1 articles about 4-(1H-benzimidazol-2-yl)-1-(3-chlorophenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(3-chlorophenyl)-5-oxopyrrolidine-3-carboxylic acid (92847-41-1) + 1,2-diamino-benzene (95-54-5) → 4-(1H-benzimidazol-2-yl)-1-(3-chlorophenyl)pyrrolidin-2-one (491874-28-3)

Guidance literature:

at 170 - 230 ℃; for 2.5h;

DOI:10.1002/hc.20171

Reference yield: 93.0%

4-(1H-benzimidazol-2-yl)-1-(3-chlorophenyl)pyrrolidin-2-one (491874-28-3) → 3-(1H-benzoimidazol-2-yl)-4-(3-chloro-phenylamino)-butyric acid

Guidance literature:

4-(1H-benzimidazol-2-yl)-1-(3-chlorophenyl)pyrrolidin-2-one; With sodium hydroxide; In water; for 4h; Heating;

With acetic acid; In water; pH=6;

DOI:10.1002/hc.20171

Reference yield: 93.0%

4-(1H-benzimidazol-2-yl)-1-(3-chlorophenyl)pyrrolidin-2-one (491874-28-3) + methyl iodide (74-88-4) → 1-(3-chloro-phenyl)-4-(1-methyl-1H-benzoimidazol-2-yl)-pyrrolidin-2-one

Guidance literature:

With potassium hydroxide; potassium carbonate; at 20 ℃;

DOI:10.1002/hc.20171

upstream raw materials:

1-(3-chlorophenyl)-5-oxopyrrolidine-3-carboxylic acid

1,2-diamino-benzene

Downstream raw materials:

1-(3-chlorophenyl)-4-[1-(5-{2-[1-(3-chlorophenyl)-2-oxotetrahydro-1H-4-pyrrolyl]-1H-benzo[d]imidazol-1-yl}pentyl)-1H-benzo[d]imidazol-2-yl]-2-pyrrolidinone

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