[2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)phenyl](thiophene-2-carbonitrile)amine

Base Information

• Chemical Name: [2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)phenyl](thiophene-2-carbonitrile)amine
• CAS No.: 1013926-24-3
• Molecular Formula: C₁₈H₁₉N₃OS
• Molecular Weight: 325.434

Synonyms:[2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)phenyl](thiophene-2-carbonitrile)amine

Chemical Property of [2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)phenyl](thiophene-2-carbonitrile)amine

Chemical Property:

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Technology Process of [2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)phenyl](thiophene-2-carbonitrile)amine

There total 1 articles about [2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)phenyl](thiophene-2-carbonitrile)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-bromo-thiophene-2-carbonitrile (18791-98-5) + 2-[(4S)-4-(tert-butyl)-4,5-dihydro-1,3-oxazol-2-yl]aniline (194350-71-5) → [2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)phenyl](thiophene-2-carbonitrile)amine (1013926-24-3)

Guidance literature:

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 120 ℃; Inert atmosphere;

DOI:10.1039/b715834c

Reference yield: 69.0%

[2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)phenyl](thiophene-2-carbonitrile)amine (1013926-24-3) + L-Phenylalaninol (3182-95-4) → {2-[(4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl]-phenyl}{2-[(4S)-4-benzyl-4,5-dihydrooxazol-2-yl]-thiophene-3-yl}amine (1013926-31-2)

Guidance literature:

With zinc(II) chloride; In chlorobenzene; at 145 ℃; for 12h; Inert atmosphere;

DOI:10.1039/b715834c

Reference yield: 68.0%

(S)-valinol (2026-48-4,473-75-6) + [2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)phenyl](thiophene-2-carbonitrile)amine (1013926-24-3) → [2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)-phenyl][2-((4S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-thiophene-3-yl]amine (1013926-34-5)

Guidance literature:

With zinc(II) chloride; In chlorobenzene; at 145 ℃; for 12h; Inert atmosphere;

DOI:10.1039/b715834c

upstream raw materials:

3-bromo-thiophene-2-carbonitrile

2-[(4S)-4-(tert-butyl)-4,5-dihydro-1,3-oxazol-2-yl]aniline

Downstream raw materials:

[2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)-phenyl][2-((4S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-thiophene-3-yl]amine

{2-[(4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl]-phenyl}{2-[(4S)-4-benzyl-4,5-dihydrooxazol-2-yl]-thiophene-3-yl}amine

[2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)-phenyl][2-((4S)-4-phenyl-4,5-dihydrooxazol-2-yl)-thiophene-3-yl]amine

[2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)-phenyl][2-((4S)-4-tert-butyl-4,5-dihydrooxazol-2-yl)-thiophene-3-yl]amine

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