N-allyl-N-(3-(2-formylphenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-allyl-N-(3-(2-formylphenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide
• CAS No.: 857026-45-0
• Molecular Formula: C₂₀H₁₉NO₃S
• Molecular Weight: 353.442
• Mol file: 857026-45-0.mol

Synonyms:N-allyl-N-(3-(2-formylphenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide

Chemical Property of N-allyl-N-(3-(2-formylphenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-allyl-N-(3-(2-formylphenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide

There total 2 articles about N-allyl-N-(3-(2-formylphenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-iodobenzaldehyde (26260-02-6) + N-tosyl-N-allylpropargylamine (133886-40-5) → N-allyl-N-(3-(2-formylphenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide (857026-45-0)

Guidance literature:

2-iodobenzaldehyde; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; for 0.166667h; Inert atmosphere;

N-tosyl-N-allylpropargylamine; Inert atmosphere;

DOI:10.1039/c9cc08286g

Reference yield: 84.0%

N-tosyl-N-allylpropargylamine (133886-40-5) + ortho-bromobenzaldehyde (6630-33-7) → N-allyl-N-(3-(2-formylphenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide (857026-45-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 50 ℃; for 20h;

DOI:10.1002/adsc.201400104

Reference yield: 95.0%

N-allyl-N-(3-(2-formylphenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide (857026-45-0) + phenylacetylene (536-74-3) → N-allyl-N-(3-(2-(1-hydroxy-3-phenylprop-2-yn-1-yl)phenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide (1382240-46-1)

Guidance literature:

phenylacetylene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

N-allyl-N-(3-(2-formylphenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1039/c9cc08286g

upstream raw materials:

2-iodobenzaldehyde

N-tosyl-N-allylpropargylamine

ortho-bromobenzaldehyde

Downstream raw materials:

C₂₇H₂₆N₂O₃S

N-allyl-N-(3-(2-(hydroxymethyl)phenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide

(E)-N-allyl-N-(3-(2-((methoxyimino)methyl)phenyl)prop-2-ynyl)-4-methylbenzenesulfonamide

C₂₈H₂₇N₃O₅S