2-Keto-4-hydroxyglutarate

Base Information

• Chemical Name: 2-Keto-4-hydroxyglutarate
• CAS No.: 1187-99-1
• Molecular Formula: C₅H₆O₆
• Molecular Weight: 162.099
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID60922759
• Wikidata: Q27102575
• Mol file: 1187-99-1.mol

Synonyms:2-keto-4-hydroxyglutarate;2-keto-4-hydroxyglutarate, (+-)-isomer

Chemical Property of 2-Keto-4-hydroxyglutarate

Chemical Property:

• Vapor Pressure: 5.01E-09mmHg at 25°C
• Boiling Point: 425.6°Cat760mmHg
• Flash Point: 225.3°C
• PSA: 111.90000
• Density: 1.7g/cm³
• LogP: -1.52430
• Storage Temp.: ?20°C
• Solubility.: Water
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 160.00078784
• Heavy Atom Count: 11
• Complexity: 184

Purity/Quality:

98%,99%, ^*data from raw suppliers

DL-4-Hydroxy-2-ketoglutarate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(C(=O)[O-])O)C(=O)C(=O)[O-]
• Uses: A 4-substituted analog of Glutamic acid A 4-substituted analog of Glutamic acid. This compound is a good enzyme substrate for GOT (glutamic oxalacetic aminotransferase).

Technology Process of 2-Keto-4-hydroxyglutarate

There total 3 articles about 2-Keto-4-hydroxyglutarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-hydroxy-2-oxoglutaric acid (1187-99-1)

Guidance literature:

With sulfuric acid;

Reference yield:

Oxalacetic acid (328-42-7) + Glyoxilic acid (298-12-4) → 4-hydroxy-2-oxoglutaric acid (1187-99-1)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 4h; pH=7.8;

DOI:10.1039/c7cc00742f

Reference yield:

→ 4-hydroxy-2-oxoglutaric acid (1187-99-1)

Guidance literature:

Na-Oxalomalonat, Salzsre.;

upstream raw materials:

Oxalacetic acid

Glyoxilic acid

Downstream raw materials:

4-hydroxyglutamate

2,4-dihydroxy-glutaric acid

4-hydroxy-5-oxo-tetrahydro-furan-2-carboxylic acid

(2S,4R)-4-hydroxyglutamic acid

Refernces

• 1、 -. "Process for producing an optically active gamma-hydroxy-L-glutamic acid". . . Retrieved 2008/06/13.