N-[4-(benzylamino)-5-carbamoylpyridine-2-yl]-N-{4-[4-(morpholinocarbonyl)piperazin-1-yl]phenyl}morpholinocarboxyamide

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Chemical Name:N-[4-(benzylamino)-5-carbamoylpyridine-2-yl]-N-{4-[4-(morpholinocarbonyl)piperazin-1-yl]phenyl}morpholinocarboxyamide
CAS No.:1227865-29-3
Molecular Formula:C₃₃H₄₀N₈O₅
Molecular Weight:628.731
Hs Code.:

Synonyms:N-[4-(benzylamino)-5-carbamoylpyridine-2-yl]-N-{4-[4-(morpholinocarbonyl)piperazin-1-yl]phenyl}morpholinocarboxyamide

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Chemical Property of N-[4-(benzylamino)-5-carbamoylpyridine-2-yl]-N-{4-[4-(morpholinocarbonyl)piperazin-1-yl]phenyl}morpholinocarboxyamide

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Technology Process of N-[4-(benzylamino)-5-carbamoylpyridine-2-yl]-N-{4-[4-(morpholinocarbonyl)piperazin-1-yl]phenyl}morpholinocarboxyamide

There total 2 articles about N-[4-(benzylamino)-5-carbamoylpyridine-2-yl]-N-{4-[4-(morpholinocarbonyl)piperazin-1-yl]phenyl}morpholinocarboxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 15159-40-7
4-morpholinocarbonyl chloride

: 1227864-55-2
4-(benzylamino)-6-({[4-piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

: 1227865-28-2
4-(benzylamino)-6-({4-[4-(morpholinocarbonyl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

: 1227865-29-3
N-[4-(benzylamino)-5-carbamoylpyridine-2-yl]-N-{4-[4-(morpholinocarbonyl)piperazin-1-yl]phenyl}morpholinocarboxyamide

Guidance literature:: With pyridine; In tetrahydrofuran; dichloromethane; at 20 ℃;

Reference yield:

: 1227864-42-7
4-(benzylamino)-6-({4-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

: 1227865-28-2
4-(benzylamino)-6-({4-[4-(morpholinocarbonyl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

: 1227865-29-3
N-[4-(benzylamino)-5-carbamoylpyridine-2-yl]-N-{4-[4-(morpholinocarbonyl)piperazin-1-yl]phenyl}morpholinocarboxyamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; barium(II) hydroxide / methanol / 0.5 h / 50 °C

2: pyridine / dichloromethane; tetrahydrofuran / 20 °C

With pyridine; water; barium(II) hydroxide; In tetrahydrofuran; methanol; dichloromethane;