ethyl 2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoate

Base Information

• Chemical Name: ethyl 2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoate
• CAS No.: 502607-15-0
• Molecular Formula: C₁₁H₁₇F₃O₃
• Molecular Weight: 254.249
• Mol file: 502607-15-0.mol

Synonyms:ethyl 2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoate

Chemical Property of ethyl 2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoate

There total 1 articles about ethyl 2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl-3,3,3-trifluoropyruvate (13081-18-0) + cyclohexylmagnesiumchloride (931-51-1) → ethyl 2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoate (502607-15-0)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1016/S0040-4020(02)00947-X

Reference yield: 98.0%

ethyl 2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoate (502607-15-0) → 2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoic acid (502607-34-3)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃;

DOI:10.1016/S0040-4020(02)00947-X

Reference yield:

ethyl 2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoate (502607-15-0) → 1-cyclohexyl-2,2,2-trifluoroethanone (6302-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / KOH / ethanol / 20 °C

2: 82 percent / Co(III) o-phenylene-bis(N'-methyloxamidate) complex; O₂; pivalaldehyde / CH₂Cl₂

With potassium hydroxide; Co(III) ortho-phenylene-bis(N'-methyloxamidate); oxygen; pivalaldehyde; In ethanol; dichloromethane;

DOI:10.1016/S0040-4020(02)00947-X

upstream raw materials:

ethyl-3,3,3-trifluoropyruvate

cyclohexylmagnesiumchloride

Downstream raw materials:

2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoic acid

1-cyclohexyl-2,2,2-trifluoroethanone

Refernces