1-CYCLOHEXYL-2,2,2-TRIFLUORO-ETHANONE

Base Information

• Chemical Name: 1-CYCLOHEXYL-2,2,2-TRIFLUORO-ETHANONE
• CAS No.: 6302-04-1
• Molecular Formula: C8H11 F3 O
• Molecular Weight: 180.17
• Hs Code.: 2914700090
• Mol file: 6302-04-1.mol

Synonyms:Ketone,cyclohexyl trifluoromethyl (8CI); 1-Cyclohexyl-2,2,2-trifluoroethanone;Cyclohexyl trifluoromethyl ketone; NSC 42756; Trifluoromethyl cyclohexyl ketone

Chemical Property of 1-CYCLOHEXYL-2,2,2-TRIFLUORO-ETHANONE

Chemical Property:

• Boiling Point: 123°C
• PSA: 17.07000
• Density: 1.169±0.06 g/cm3(Predicted)
• LogP: 2.69810

Purity/Quality:

99% ^*data from raw suppliers

1-CYCLOHEXYL-2,2,2-TRIFLUORO-ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-CYCLOHEXYL-2,2,2-TRIFLUORO-ETHANONE

There total 13 articles about 1-CYCLOHEXYL-2,2,2-TRIFLUORO-ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoic acid (502607-34-3) → 1-cyclohexyl-2,2,2-trifluoroethanone (6302-04-1)

Guidance literature:

With Co(III) ortho-phenylene-bis(N'-methyloxamidate); oxygen; pivalaldehyde; In dichloromethane;

DOI:10.1016/S0040-4020(02)00947-X

Reference yield: 75.0%

1-cyclohexyl-2,2,2-trifluoroethanol (107018-38-2) → 1-cyclohexyl-2,2,2-trifluoroethanone (6302-04-1)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1016/S0040-4039(00)96479-7

Reference yield: 72.0%

methyl cyclohexylcarboxylate (4630-82-4) + (trifluoromethyl)trimethylsilane (81290-20-2) → 1-cyclohexyl-2,2,2-trifluoroethanone (6302-04-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; pentane; for 48h; Ambient temperature;

DOI:10.1002/(SICI)1521-3773(19980403)37:6<820::AID-ANIE820>3.0.CO;2-M

upstream raw materials:

trifluoroacetic acid

cyclohexylmagnesium bromide

1-bromocyclohexane

sodium 2,2,2-trifluoroacetate

Downstream raw materials:

2-(1-Cyclohexyl-2,2,2-trifluoro-ethylidene)-[1,3]dithiane

C₂₁H₂₁F₃S₂

3,3,3-trifluoro-2-cyclohexyl propanal

(1R)-1-(cyclohexyl)-2,2,2-trifluoroethanol