(1R,2S)-1-phenylsulfonyl-2-(hydroxymethyl)-N,N-diethylcyclopropanecarboxamide

Base Information

Chemical Name:(1R,2S)-1-phenylsulfonyl-2-(hydroxymethyl)-N,N-diethylcyclopropanecarboxamide
CAS No.:408348-32-3
Molecular Formula:C₁₅H₂₁NO₄S
Molecular Weight:311.402
Hs Code.:

Synonyms:(1R,2S)-1-phenylsulfonyl-2-(hydroxymethyl)-N,N-diethylcyclopropanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S)-1-phenylsulfonyl-2-(hydroxymethyl)-N,N-diethylcyclopropanecarboxamide

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Technology Process of (1R,2S)-1-phenylsulfonyl-2-(hydroxymethyl)-N,N-diethylcyclopropanecarboxamide

There total 3 articles about (1R,2S)-1-phenylsulfonyl-2-(hydroxymethyl)-N,N-diethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 109-89-7
diethylamine

: 408348-28-7
(1R,5S)-1-(phenylsulfonyl)-3-oxabicyclo[3.1.0]hexan-2-one

: 408348-32-3
(1R,2S)-1-phenylsulfonyl-2-(hydroxymethyl)-N,N-diethylcyclopropanecarboxamide

Guidance literature:: With aluminium trichloride; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1021/jo010852x

Reference yield:

: 7605-28-9
2-(phenylsulfonyl)acetonitrile

: 408348-32-3
(1R,2S)-1-phenylsulfonyl-2-(hydroxymethyl)-N,N-diethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: EtONa / ethanol / 12 h / 20 °C

2: 15.6 g / aq. AcOH / 5 h / 20 °C / pH 3

3: 97 percent / AlCl₃ / CH₂Cl₂ / 5 h / 20 °C

With aluminium trichloride; sodium ethanolate; acetic acid; In ethanol; dichloromethane;
DOI:10.1021/jo010852x

Reference yield:

: (1R,2S)-1-Benzenesulfonyl-2-hydroxymethyl-cyclopropanecarbonitrile

: 408348-32-3
(1R,2S)-1-phenylsulfonyl-2-(hydroxymethyl)-N,N-diethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 15.6 g / aq. AcOH / 5 h / 20 °C / pH 3

2: 97 percent / AlCl₃ / CH₂Cl₂ / 5 h / 20 °C

With aluminium trichloride; acetic acid; In dichloromethane;
DOI:10.1021/jo010852x