(E)-N-(1-(2,4,5-trimethoxyphenyl)hexa-1,5-dien-3-yl)acrylamide

Base Information

• Chemical Name: (E)-N-(1-(2,4,5-trimethoxyphenyl)hexa-1,5-dien-3-yl)acrylamide
• CAS No.: 1380294-19-8
• Molecular Formula: C₁₈H₂₃NO₄
• Molecular Weight: 317.385
• Mol file: 1380294-19-8.mol

Synonyms:(E)-N-(1-(2,4,5-trimethoxyphenyl)hexa-1,5-dien-3-yl)acrylamide

Chemical Property of (E)-N-(1-(2,4,5-trimethoxyphenyl)hexa-1,5-dien-3-yl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(1-(2,4,5-trimethoxyphenyl)hexa-1,5-dien-3-yl)acrylamide

There total 4 articles about (E)-N-(1-(2,4,5-trimethoxyphenyl)hexa-1,5-dien-3-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H21NO3 + acryloyl chloride (814-68-6,25189-84-8) → (E)-N-(1-(2,4,5-trimethoxyphenyl)hexa-1,5-dien-3-yl)acrylamide (1380294-19-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.03.059

Reference yield:

trans 2,4,5-trimethoxy cinnamaldehyde (99217-07-9,106128-88-5,99217-06-8) → (E)-N-(1-(2,4,5-trimethoxyphenyl)hexa-1,5-dien-3-yl)acrylamide (1380294-19-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 0.5 h / 0 - 20 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2012.03.059

Reference yield:

asaraldehyde (4460-86-0,14374-62-0) → (E)-N-(1-(2,4,5-trimethoxyphenyl)hexa-1,5-dien-3-yl)acrylamide (1380294-19-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3.5 h / 80 °C / Air atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

4.2: 0.5 h / 0 - 20 °C / Inert atmosphere

4.3: 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; diisobutylaluminium hydride; triethylamine; lithium hexamethyldisilazane; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil; 1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;

DOI:10.1016/j.bmc.2012.03.059

upstream raw materials:

acryloyl chloride

asaraldehyde

trans-2,4,5-trimethoxycinnamic acid ethyl ester

trans 2,4,5-trimethoxy cinnamaldehyde