2,4,5-trimethoxycinnamic acid ethyl ester

Base Information

• Chemical Name: 2,4,5-trimethoxycinnamic acid ethyl ester
• CAS No.: 14469-89-7
• Molecular Formula: C₁₄H₁₈O₅
• Molecular Weight: 266.294
• Mol file: 14469-89-7.mol

Synonyms:2,4,5-trimethoxycinnamic acid ethyl ester

Chemical Property of 2,4,5-trimethoxycinnamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,5-trimethoxycinnamic acid ethyl ester

There total 7 articles about 2,4,5-trimethoxycinnamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + asaraldehyde (4460-86-0,14374-62-0) → 2,4,5-trimethoxycinnamic acid ethyl ester (14469-89-7)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; for 20h; Reflux;

DOI:10.1016/j.tetlet.2012.06.088

Reference yield: 88.0%

(E)-3-(2,4,5-trimethoxyphenyl)prop-2-enoic acid (73490-49-0) + chloroformic acid ethyl ester (541-41-3) → trans-2,4,5-trimethoxycinnamic acid ethyl ester (14469-89-7,80152-43-8)

Guidance literature:

With triethylamine; In acetonitrile; for 0.166667h; microwave irradiation, cooling;

DOI:10.1002/hlca.200590058

Reference yield: 60.0%

cycl-isopropylidene malonate (2033-24-1) + ethanol (64-17-5) + asaraldehyde (4460-86-0,14374-62-0) → trans-2,4,5-trimethoxycinnamic acid ethyl ester (14469-89-7,80152-43-8)

Guidance literature:

cycl-isopropylidene malonate; ethanol; In toluene; at 110 ℃; for 4h;

asaraldehyde; With piperidine; pyridine; In toluene; for 18h; Reflux;

upstream raw materials:

asaraldehyde

ethyl acetate

(E)-3-(2,4,5-trimethoxyphenyl)prop-2-enoic acid

chloroformic acid ethyl ester

Downstream raw materials:

ethyl (Z)-3-(2,4,5-trimethoxyphenyl)-3-(4-methoxyphenyl)acrylate

trans 2,4,5-trimethoxy cinnamaldehyde

(E)-6-(2,4,5-trimethoxystyryl)-5,6-dihydro-2H-pyran-2-one

(E)-1-(2,4,5-trimethoxyphenyl)hexa-1,5-dien-3-yl acrylate