3-{[5-(3-fluoro-4-{5-[1-(trifluoromethyl)cyclopropyl]-1H-imidazol-2-yl}phenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoic acid

Base Information

Chemical Name:3-{[5-(3-fluoro-4-{5-[1-(trifluoromethyl)cyclopropyl]-1H-imidazol-2-yl}phenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoic acid
CAS No.:1383000-32-5
Molecular Formula:C₂₄H₂₃F₄N₃O₃
Molecular Weight:477.459
Hs Code.:

Synonyms:3-{[5-(3-fluoro-4-{5-[1-(trifluoromethyl)cyclopropyl]-1H-imidazol-2-yl}phenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoic acid

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Chemical Property of 3-{[5-(3-fluoro-4-{5-[1-(trifluoromethyl)cyclopropyl]-1H-imidazol-2-yl}phenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoic acid

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Technology Process of 3-{[5-(3-fluoro-4-{5-[1-(trifluoromethyl)cyclopropyl]-1H-imidazol-2-yl}phenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoic acid

There total 8 articles about 3-{[5-(3-fluoro-4-{5-[1-(trifluoromethyl)cyclopropyl]-1H-imidazol-2-yl}phenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₅F₄N₃O₃

: 1383000-32-5
3-{[5-(3-fluoro-4-{5-[1-(trifluoromethyl)cyclopropyl]-1H-imidazol-2-yl}phenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoic acid

Guidance literature:: C₂₅H₂₅F₄N₃O₃; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; ethyl acetate;

Reference yield:

: 105942-08-3
4-bromo-6-fluorobenzonitrile

: 1383000-32-5
3-{[5-(3-fluoro-4-{5-[1-(trifluoromethyl)cyclopropyl]-1H-imidazol-2-yl}phenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 7 h / 60 °C / Inert atmosphere

2.1: hydroxylamine / tetrahydrofuran; methanol; water / 5 h / 80 °C

3.1: 5 h / 20 °C

3.2: 13 h / 20 °C

4.1: potassium carbonate / dichloromethane; water / 8 h / 50 °C

5.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 50 °C

With water; hydroxylamine; sodium carbonate; potassium carbonate; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 277756-46-4
1-(trifluoromethyl)cyclopropanecarboxylic acid

: 1383000-32-5
3-{[5-(3-fluoro-4-{5-[1-(trifluoromethyl)cyclopropyl]-1H-imidazol-2-yl}phenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.1: hexane; acetonitrile / 1.5 h / 0 - 20 °C

2.2: 0.5 h / 0 °C

3.1: potassium carbonate / dichloromethane; water / 8 h / 50 °C

4.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 50 °C

With oxalyl dichloride; water; potassium carbonate; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;