277756-46-4

Basic information

• Product Name: 1-TRIFLUOROMETHYLCYCLOPROPANE-1-CARBOXYLIC ACID
• Synonyms: 1-TRIFLUOROMETHYLCYCLOPROPANE-1-CARBOXYLIC ACID;1-(TRIFLUOROMETHYL)CYCLOPROPANE-1-CARBO&;Cyclopropanecarboxylic acid, 1-(trifluoromethyl)- (9CI);1-(Trifluoromethyl)cyclopropane-1-carboxylic acid 99%;1-(Trifluoromethyl)cyclopropane-1-carboxylicacid99%;1-TRIFLUOROMETHYLCYCLOPROPANECARBOXYLIC ACID;1-Trifluoromethylcyclopropane-1-carboxylic acid ,97%;1-Carboxy-1-(trifluoromethyl)cyclopropane
• CAS NO: 277756-46-4
• Molecular Formula: C₅H₅F₃O₂
• Molecular Weight: 154.09
• EINECS: -0
• Product Categories: CARBOXYLICACID;C1 to C5;Carbonyl Compounds;Carboxylic Acids;Aliphatics;Chiral Reagents
• Mol File: 277756-46-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 86 °C
• Boiling Point: 182-184°C
• Flash Point: 182-184°C
• Appearance: /
• Density: 1.588g/cm³
• Vapor Pressure: 1.29mmHg at 25°C
• Refractive Index: 1.421
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.03±0.20(Predicted)
• BRN: 8543283
• CAS DataBase Reference: 1-TRIFLUOROMETHYLCYCLOPROPANE-1-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TRIFLUOROMETHYLCYCLOPROPANE-1-CARBOXYLIC ACID(277756-46-4)
• EPA Substance Registry System: 1-TRIFLUOROMETHYLCYCLOPROPANE-1-CARBOXYLIC ACID(277756-46-4)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-22
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 277756-46-4(Hazardous Substances Data)

Usage

Chemical Properties

Solid

Uses

Different sources of media describe the Uses of 277756-46-4 differently. You can refer to the following data:
1. An intermediate in the preparation of MK-5046, a potent, selective bombesin receptor subtype-3 agonist for the treatment of obesity.
2. A intermediate in the preparation of MK-5046, a potent, selective bombesin receptor subtype-3 agonist for the treatment of obesity.

InChI:InChI=1/C5H5F3O2/c6-5(7,8)4(1-2-4)3(9)10/h1-2H2,(H,9,10)

Upstream product

• 598-10-7 cyclopropane-1,1-dicarboxylic acid 
• 1559-02-0 diethyl cyclopropane-1,1-dicarboxylate 

Downstream Products

• 208242-25-5 methayl 1-(trifluoromethyl)cyclopropanecarboxylate 
• 1318780-16-3 N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaboran-2-yl)phenyl)-1-(trifluoromethyl)cyclopropanecarboxamide 
• 1354043-63-2 C₂₂H₁₇F₄N₇O₂ 
• 1354043-22-3 C₂₂H₁₇F₄N₇O₂ 
• 1628184-67-7 1-(trifluoromethyl)cyclopropane-1-carboxamide 
• 1423304-33-9 6-benzyl-2-(1-(trifluoromethyl)cyclopropyl)-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 1383733-54-7 tert-butyl {(5R,6S,8S)-5-methyl-6-phenyl-3-[1-(trifluoromethyl)cyclopropyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-yl}carbamate 
• 1382999-84-9 methyl 2,2-dimethyl-3-[4-(4-methyl-5-{5-[1-(trifluoromethyl)cyclopropyl]-1H-imidazol-2-yl}pyridin-2-yl)phenoxy]propanoate 
• 1383000-32-5 3-{[5-(3-fluoro-4-{5-[1-(trifluoromethyl)cyclopropyl]-1H-imidazol-2-yl}phenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoic acid 
• 1381846-16-7 2-Chloro-N-(1H-imidazol-2-yl)-5-[[[1-(trifluoromethyl)cyclopropanecarbonyl]amino]methyl]benzamide 
• 1360569-11-4 (3R,4R,5S,6R)-2-(4-fluoro-3-(4-((1-(trifluoromethyl)cyclopropyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 1360569-10-3 (3R,4S,5S,6R)-2-(4-fluoro-3-(4-((1-( trifluoromethyl)cyclopropyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 
• 1360569-09-0 4-bromo-1-fluoro-2-(4-((1-(trifluoromethyl)cyclopropyl)methoxy)benzyl)benzene 
• 1360569-02-3 (3R,4R,5S,6R)-2-(4-chloro-3-(4-((1-(trifluoromethyl)cyclopropyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 

Relevant articles and documents

Preparation method and intermediate of 1-(-trifluoromethyl) cyclopropane -1- carboxylic acid compound (by machine translation)

The invention relates to a preparation method 1 - (of) trifluoromethyl I cyclopropane - 1 1-carboxylic acid type, compound, which is a novel, effective and safe and environment-friendly preparation method. of 1 - (-trifluoromethyl) cyclopropane - 1 1-carboxylic acid as a medicine intermediate body for preparing a final drug. (by machine translation)

Preparation method of trifluoromethyl substituted carboxylic acid compound

The invention provides a preparation method of a trifluoromethyl substituted carboxylic acid compound. The method is significantly advantageous over processes in the prior art. Advantages are reflected in low cost and high yield. Another alternative schem