1-methyl-4-phenylmethylene-1-azacyclohexane

Base Information

• Chemical Name: 1-methyl-4-phenylmethylene-1-azacyclohexane
• CAS No.: 106165-50-8
• Molecular Formula: C₁₃H₁₇N
• Molecular Weight: 187.285
• Mol file: 106165-50-8.mol

Synonyms:1-methyl-4-phenylmethylene-1-azacyclohexane

Chemical Property of 1-methyl-4-phenylmethylene-1-azacyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-methyl-4-phenylmethylene-1-azacyclohexane

There total 3 articles about 1-methyl-4-phenylmethylene-1-azacyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-Methyl-4-piperidone (1445-73-4) + O,O-diethyl benzylphosphonate (1080-32-6) → 1-methyl-4-phenylmethylene-1-azacyclohexane (106165-50-8)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane; for 1h; Heating;

DOI:10.1021/jo9813538

Reference yield:

1-Methyl-4-brom-4-piperidyl-phenylketon (804428-11-3) → 1-methyl-4-phenylmethylene-1-azacyclohexane (106165-50-8)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/jo01085a012

Reference yield:

diethyl ether (60-29-7,927820-24-4) + (4-bromo-1-methyl-[4]piperidyl)-phenyl ketone; hydrobromide (92020-38-7) → 1-methyl-4-phenylmethylene-1-azacyclohexane (106165-50-8) + (1-methylpiperidin-4-yl)(phenyl)methanol (92196-29-7) + (1-Methyl-1,2,3,6-tetrahydro-[4]pyridyl)-phenyl-methanol (107416-38-6)

Guidance literature:

DOI:10.1021/jo01085a012

upstream raw materials:

1-Methyl-4-piperidone

O,O-diethyl benzylphosphonate

1-Methyl-4-brom-4-piperidyl-phenylketon

diethyl ether