N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
• CAS No.: 1202389-42-1
• Molecular Formula: C₂₁H₂₄BrClN₆O
• Molecular Weight: 491.818

Synonyms:N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Chemical Property of N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

There total 2 articles about N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + N2-(4-bromo-2,5-dimethylphenyl)-5-chloro-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (1202389-41-0) → N2-(4-bromo-2,5-dimethylphenyl)-5-chloro-N4-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (1202389-42-1)

Guidance literature:

3,4-dihydro-2H-pyran; N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine; toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃; for 14h;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

2,5-dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine (543712-81-8) → N2-(4-bromo-2,5-dimethylphenyl)-5-chloro-N4-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (1202389-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water; isopropyl alcohol / 1.67 h / 130 °C / microwave

2: toluene-4-sulfonic acid / tetrahydrofuran / 14 h / 20 °C

With hydrogenchloride; toluene-4-sulfonic acid; In tetrahydrofuran; water; isopropyl alcohol;

Reference yield:

N2-(4-bromo-2,5-dimethylphenyl)-5-chloro-N4-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (1202389-42-1) + tributyl(1-ethoxyvinyl)stannane (97674-02-7) → 1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone (1202389-43-2)

Guidance literature:

N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine; tributyl(1-ethoxyvinyl)stannane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; for 14h; Inert atmosphere;

With hydrogenchloride; water; In acetonitrile; for 14h;

upstream raw materials:

3,4-dihydro-2H-pyran

N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

2,5-dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine

Downstream raw materials:

1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone

1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone O-2-hydroxyethyl oxime

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1202389-42-1 N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send