4-METHOXYCATECHOL

Base Information

• Chemical Name: 4-METHOXYCATECHOL
• CAS No.: 3934-97-2
• Molecular Formula: C7H8 O3
• Molecular Weight: 140.139
• Hs Code.: 2909500000
• Mol file: 3934-97-2.mol

Synonyms:Pyrocatechol,4-methoxy- (6CI,7CI,8CI); 1,2-Dihydroxy-4-methoxybenzene;2-Hydroxy-4-methoxyphenol; 4-Methoxycatechol; 4-Methoxypyrocatechol;p-Methoxycatechol

Chemical Property of 4-METHOXYCATECHOL

Chemical Property:

• Vapor Pressure: 0.000395mmHg at 25°C
• Melting Point: 48-50 °C
• Boiling Point: 307.6°Cat760mmHg
• PKA: 9.42±0.10(Predicted)
• Flash Point: 139.8°C
• PSA: 49.69000
• Density: 1.27g/cm³
• LogP: 1.10640
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

4-methoxybenzene-1,2-diol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXYCATECHOL

There total 27 articles about 4-METHOXYCATECHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) → 4-methoxycatechol (3934-97-2)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃; for 1h;

DOI:10.1002/hlca.200690071

Reference yield: 90.0%

1,2-dibenzyloxy-4-methoxybenzene (88755-15-1) → 4-methoxycatechol (3934-97-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 40 ℃; for 19h;

Reference yield: 79.0%

4-methoxy-phenol (150-76-5) → 4-methoxycatechol (3934-97-2)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In N,N-dimethyl-formamide; at 20 - 23 ℃; for 4h;

DOI:10.1002/anie.201606359

upstream raw materials:

2-hydroxy-5-methoxybenzaldehyde

2-Acetoxy-4-methoxy-phenol

2-Hydroxy-4-methoxybenzaldehyde

1-(2-hydroxy-4-methoxyphenyl)ethanone

Downstream raw materials:

3,4-bis(tosyloxy)anisole

1,2-dibenzyloxy-4-methoxybenzene

obtusaquinone

2-(acetoxy)-5-methoxyphenyl acetate

Refernces

• 1、 Kroc, Michelle A.,Patil, Aditi,Carlos, Anthony,Ballantine, Josiah,Aguilar, Stephanie,Mo, Dong-Liang,Wang, Heng-Yen,Mueller, Daniel S.,Wink, Donald J.,Anderson, Laura L.. "Synthesis of α-oxygenated ketones and substituted catechols via the rearrangement of N-enoxy- and N-aryloxyphthalimides". . p. 4125 - 4137. Retrieved 2017/06/29.
• 2、 Saikia, Bishwajit,Borah, Parinita,Barua, Nabin Chandra. "H2O2 in WEB: a highly efficient catalyst system for the Dakin reaction". supporting information. p. 4533 - 4536. Retrieved 2015/09/15.