Benzene, 4-methoxy-1,2-bis(phenylmethoxy)-

Base Information

• Chemical Name: Benzene, 4-methoxy-1,2-bis(phenylmethoxy)-
• CAS No.: 88755-15-1
• Molecular Formula: C21H20O3
• Molecular Weight: 320.388
• DSSTox Substance ID: DTXSID90472530
• Wikidata: Q82301504
• Mol file: 88755-15-1.mol

Synonyms:Benzene, 4-methoxy-1,2-bis(phenylmethoxy)-;88755-15-1;DTXSID90472530

Chemical Property of Benzene, 4-methoxy-1,2-bis(phenylmethoxy)-

Chemical Property:

• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 320.14124450
• Heavy Atom Count: 24
• Complexity: 334

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)OCC2=CC=CC=C2)OCC3=CC=CC=C3

Technology Process of Benzene, 4-methoxy-1,2-bis(phenylmethoxy)-

There total 11 articles about Benzene, 4-methoxy-1,2-bis(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dibenzyloxyphenol (27688-86-4) + dimethyl sulfate (77-78-1) → 1,2-dibenzyloxy-4-methoxybenzene (88755-15-1)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 17h;

DOI:10.1271/bbb.63.1453

Reference yield: 67.0%

3,4-dibenzyloxyphenol (27688-86-4) + methyl iodide (74-88-4) → 1,2-dibenzyloxy-4-methoxybenzene (88755-15-1)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Heating;

DOI:10.1016/j.tet.2005.06.040

Reference yield:

3,4-dibenzyloxybenzaldehyde (5447-02-9) → 1,2-dibenzyloxy-4-methoxybenzene (88755-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / boric acid; aq. H₂O₂; aq. H₂SO₄ / tetrahydrofuran / 12 h / 20 °C

2: 67 percent / potassium carbonate / acetone / 6 h / Heating

With sulfuric acid; dihydrogen peroxide; boric acid; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1016/j.tet.2005.06.040

upstream raw materials:

3,4-dibenzyloxyphenol

dimethyl sulfate

methyl iodide

4-methoxycatechol

Downstream raw materials:

4-methoxycatechol

4,5-dibenzyloxy-2-methoxybenzaldehyde

1,2-di-O-benzyl-3-(8'-drimen-11'-yl)-4-O-methylbenzenetriol

1,2-di-O-benzyl-3-(11'-hydroxy-8'-drimen-11'-yl)-4-O-methylbenzenetriol