benzyl 4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidine]-1'-carboxylate

Base Information

Chemical Name:benzyl 4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidine]-1'-carboxylate
CAS No.:911228-43-8
Molecular Formula:C₂₂H₂₃NO₃
Molecular Weight:349.43
Hs Code.:

Synonyms:benzyl 4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidine]-1'-carboxylate

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Chemical Property of benzyl 4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidine]-1'-carboxylate

Chemical Property:

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Technology Process of benzyl 4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidine]-1'-carboxylate

There total 5 articles about benzyl 4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.2%

: 1013335-13-1
C₁₄H₁₇NO

: 501-53-1,94274-21-2
benzyl chloroformate

: 911228-43-8
benzyl 4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidine]-1'-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: C₂₂H₂₄ClNO₃

: 501-53-1,94274-21-2
benzyl chloroformate

: 911228-43-8
benzyl 4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidine]-1'-carboxylate

Guidance literature:: C₂₂H₂₄ClNO₃; With aluminum (III) chloride; In dichloromethane; at 20 ℃; Inert atmosphere;

benzyl chloroformate; With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/j.tet.2009.04.094

Reference yield:

: 911228-42-7
4-benzyl-4-(cyano-ethoxycarbonyl-methylene)-piperidine-1-carboxylic acid benzyl ester

: 911228-43-8
benzyl 4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidine]-1'-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 0 - 90 °C

2: triethylamine / dichloromethane / 1 h / 0 °C

With sulfuric acid; triethylamine; In dichloromethane;