(S)-4-Amino-5-[(S)-2-amino-4-(trityl-carbamoyl)-butyldisulfanyl]-pentanoic acid trityl-amide

Base Information

Chemical Name:(S)-4-Amino-5-[(S)-2-amino-4-(trityl-carbamoyl)-butyldisulfanyl]-pentanoic acid trityl-amide
CAS No.:213487-85-5
Molecular Formula:C₄₈H₅₀N₄O₂S₂
Molecular Weight:779.083
Hs Code.:

Synonyms:(S)-4-Amino-5-[(S)-2-amino-4-(trityl-carbamoyl)-butyldisulfanyl]-pentanoic acid trityl-amide

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Chemical Property of (S)-4-Amino-5-[(S)-2-amino-4-(trityl-carbamoyl)-butyldisulfanyl]-pentanoic acid trityl-amide

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Technology Process of (S)-4-Amino-5-[(S)-2-amino-4-(trityl-carbamoyl)-butyldisulfanyl]-pentanoic acid trityl-amide

There total 5 articles about (S)-4-Amino-5-[(S)-2-amino-4-(trityl-carbamoyl)-butyldisulfanyl]-pentanoic acid trityl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 213488-18-7
[(S)-1-[(S)-2-tert-Butoxycarbonylamino-4-(trityl-carbamoyl)-butyldisulfanylmethyl]-3-(trityl-carbamoyl)-propyl]-carbamic acid tert-butyl ester

: 213487-85-5
(S)-4-Amino-5-[(S)-2-amino-4-(trityl-carbamoyl)-butyldisulfanyl]-pentanoic acid trityl-amide

Guidance literature:: With boron trifluoride diethyl etherate; acetic acid; for 1h;
DOI:10.1021/jm981015z

Reference yield:

: 132388-69-3,210750-95-1
Boc-L-Gln(Trt)-OH

: 213487-85-5
(S)-4-Amino-5-[(S)-2-amino-4-(trityl-carbamoyl)-butyldisulfanyl]-pentanoic acid trityl-amide

Guidance literature:: Multi-step reaction with 5 steps

1: NMM / 1,2-dimethoxy-ethane / -15 °C

2: 70 percent / NaBH₄

3: 40 percent / PPh₃, (i-PrN=)2

4: 87 percent / 1 N NaOH, I₂ / methanol / 3 h / Ambient temperature

5: 82 percent / (C₂H₅)2O*BF₃, AcOH / 1 h

With 4-methyl-morpholine; sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; iodine; acetic acid; triphenylphosphine; N,N'-diisopropyldiazene; In methanol; 1,2-dimethoxyethane;
DOI:10.1021/jm981015z

Reference yield:

: C₃₄H₄₀N₂O₇

: 213487-85-5
(S)-4-Amino-5-[(S)-2-amino-4-(trityl-carbamoyl)-butyldisulfanyl]-pentanoic acid trityl-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / NaBH₄

2: 40 percent / PPh₃, (i-PrN=)2

3: 87 percent / 1 N NaOH, I₂ / methanol / 3 h / Ambient temperature

4: 82 percent / (C₂H₅)2O*BF₃, AcOH / 1 h

With sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; iodine; acetic acid; triphenylphosphine; N,N'-diisopropyldiazene; In methanol;
DOI:10.1021/jm981015z