Boc-Gln[Trt]-Ol

Base Information

• Chemical Name: Boc-Gln[Trt]-Ol
• CAS No.: 213488-16-5
• Molecular Formula: C29H34 N2 O4
• Molecular Weight: 474.59
• Mol file: 213488-16-5.mol

Synonyms:Boc-Gln[Trt]-Ol

Chemical Property of Boc-Gln[Trt]-Ol

Chemical Property:

• PSA: 87.66000
• LogP: 5.54230

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boc-Gln[Trt]-Ol

There total 2 articles about Boc-Gln[Trt]-Ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C34H40N2O7 → [(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propyl]-carbamic acid tert-butyl ester (213488-16-5)

Guidance literature:

With sodium tetrahydroborate;

DOI:10.1021/jm981015z

Reference yield:

Boc-L-Gln(Trt)-OH (132388-69-3,210750-95-1) → [(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propyl]-carbamic acid tert-butyl ester (213488-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NMM / 1,2-dimethoxy-ethane / -15 °C

2: 70 percent / NaBH₄

With 4-methyl-morpholine; sodium tetrahydroborate; In 1,2-dimethoxyethane;

DOI:10.1021/jm981015z

Reference yield: 40.0%

tiolacetic acid (507-09-5) + [(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propyl]-carbamic acid tert-butyl ester (213488-16-5) → Thioacetic acid S-[(S)-2-tert-butoxycarbonylamino-4-(trityl-carbamoyl)-butyl] ester (213488-17-6)

Guidance literature:

With triphenylphosphine; N,N'-diisopropyldiazene;

DOI:10.1021/jm981015z

upstream raw materials:

Boc-L-Gln(Trt)-OH

Downstream raw materials:

Thioacetic acid S-[(S)-2-tert-butoxycarbonylamino-4-(trityl-carbamoyl)-butyl] ester

(S)-4-Amino-5-[(S)-2-amino-4-(trityl-carbamoyl)-butyldisulfanyl]-pentanoic acid trityl-amide

[(S)-1-[(S)-2-tert-Butoxycarbonylamino-4-(trityl-carbamoyl)-butyldisulfanylmethyl]-3-(trityl-carbamoyl)-propyl]-carbamic acid tert-butyl ester

Refernces