3-[N-(4-Chloro-3-methylisoxazol-5-yl)sulfamoyl]-N-(3-hydroxy-2,4,6-trimethylphenyl)thiophene-2-carboxamide

Base Information

Chemical Name:3-[N-(4-Chloro-3-methylisoxazol-5-yl)sulfamoyl]-N-(3-hydroxy-2,4,6-trimethylphenyl)thiophene-2-carboxamide
CAS No.:205515-63-5
Molecular Formula:C₁₈H₁₈ClN₃O₅S₂
Molecular Weight:455.943
Hs Code.:

Synonyms:3-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-N-{3-hydroxy-2,4,6-trimethylphenyl}-2-thiophenecarboxamide

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Chemical Property of 3-[N-(4-Chloro-3-methylisoxazol-5-yl)sulfamoyl]-N-(3-hydroxy-2,4,6-trimethylphenyl)thiophene-2-carboxamide

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Technology Process of 3-[N-(4-Chloro-3-methylisoxazol-5-yl)sulfamoyl]-N-(3-hydroxy-2,4,6-trimethylphenyl)thiophene-2-carboxamide

There total 10 articles about 3-[N-(4-Chloro-3-methylisoxazol-5-yl)sulfamoyl]-N-(3-hydroxy-2,4,6-trimethylphenyl)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 250651-12-8
acetic acid 3-({3-[(4-chloro-3-methyl-isoxazol-5-yl)-methoxymethyl-sulfamoyl]-thiophene-2-carbonyl}-amino)-2,4,6-trimethyl-phenyl ester

: 205515-63-5
3-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-N-{3-hydroxy-2,4,6-trimethylphenyl}-2-thiophenecarboxamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; Heating;
DOI:10.1021/jm9900063

Reference yield:

: 527-60-6
Mesitol

: 205515-63-5
3-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-N-{3-hydroxy-2,4,6-trimethylphenyl}-2-thiophenecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N

2: 70 percent HNO₃; conc. H₂SO₄; AcOH / 1 h

3: Fe; AcOH / 1 h / 90 - 110 °C

4: tetrahydrofuran / 20 °C

5: 65 percent / conc. HCl / tetrahydrofuran / Heating

With hydrogenchloride; sulfuric acid; nitric acid; iron; acetic acid; triethylamine; In tetrahydrofuran; 1: Acetylation / 2: Nitration / 3: Reduction / 4: Acylation / 5: Deacetylation;
DOI:10.1021/jm9900063

Reference yield:

: 115231-65-7
acetic acid-(2,4,6-trimethyl-3-nitro-phenyl ester)

: 205515-63-5
3-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-N-{3-hydroxy-2,4,6-trimethylphenyl}-2-thiophenecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: Fe; AcOH / 1 h / 90 - 110 °C

2: tetrahydrofuran / 20 °C

3: 65 percent / conc. HCl / tetrahydrofuran / Heating

With hydrogenchloride; iron; acetic acid; In tetrahydrofuran; 1: Reduction / 2: Acylation / 3: Deacetylation;
DOI:10.1021/jm9900063