acetic acid 3-({3-[(4-chloro-3-methyl-isoxazol-5-yl)-methoxymethyl-sulfamoyl]-thiophene-2-carbonyl}-amino)-2,4,6-trimethyl-phenyl ester

Base Information

Chemical Name:acetic acid 3-({3-[(4-chloro-3-methyl-isoxazol-5-yl)-methoxymethyl-sulfamoyl]-thiophene-2-carbonyl}-amino)-2,4,6-trimethyl-phenyl ester
CAS No.:250651-12-8
Molecular Formula:C₂₂H₂₄ClN₃O₇S₂
Molecular Weight:542.033
Hs Code.:

Synonyms:acetic acid 3-({3-[(4-chloro-3-methyl-isoxazol-5-yl)-methoxymethyl-sulfamoyl]-thiophene-2-carbonyl}-amino)-2,4,6-trimethyl-phenyl ester

Suppliers and Price of acetic acid 3-({3-[(4-chloro-3-methyl-isoxazol-5-yl)-methoxymethyl-sulfamoyl]-thiophene-2-carbonyl}-amino)-2,4,6-trimethyl-phenyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of acetic acid 3-({3-[(4-chloro-3-methyl-isoxazol-5-yl)-methoxymethyl-sulfamoyl]-thiophene-2-carbonyl}-amino)-2,4,6-trimethyl-phenyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of acetic acid 3-({3-[(4-chloro-3-methyl-isoxazol-5-yl)-methoxymethyl-sulfamoyl]-thiophene-2-carbonyl}-amino)-2,4,6-trimethyl-phenyl ester

There total 6 articles about acetic acid 3-({3-[(4-chloro-3-methyl-isoxazol-5-yl)-methoxymethyl-sulfamoyl]-thiophene-2-carbonyl}-amino)-2,4,6-trimethyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 527-60-6
Mesitol

: 250651-12-8
acetic acid 3-({3-[(4-chloro-3-methyl-isoxazol-5-yl)-methoxymethyl-sulfamoyl]-thiophene-2-carbonyl}-amino)-2,4,6-trimethyl-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N

2: 70 percent HNO₃; conc. H₂SO₄; AcOH / 1 h

3: Fe; AcOH / 1 h / 90 - 110 °C

4: tetrahydrofuran / 20 °C

With sulfuric acid; nitric acid; iron; acetic acid; triethylamine; In tetrahydrofuran; 1: Acetylation / 2: Nitration / 3: Reduction / 4: Acylation;
DOI:10.1021/jm9900063

Reference yield:

: 115231-65-7
acetic acid-(2,4,6-trimethyl-3-nitro-phenyl ester)

: 250651-12-8
acetic acid 3-({3-[(4-chloro-3-methyl-isoxazol-5-yl)-methoxymethyl-sulfamoyl]-thiophene-2-carbonyl}-amino)-2,4,6-trimethyl-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Fe; AcOH / 1 h / 90 - 110 °C

2: tetrahydrofuran / 20 °C

With iron; acetic acid; In tetrahydrofuran; 1: Reduction / 2: Acylation;
DOI:10.1021/jm9900063

Reference yield:

: 19082-49-6
mesityl acetate

: 250651-12-8
acetic acid 3-({3-[(4-chloro-3-methyl-isoxazol-5-yl)-methoxymethyl-sulfamoyl]-thiophene-2-carbonyl}-amino)-2,4,6-trimethyl-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent HNO₃; conc. H₂SO₄; AcOH / 1 h

2: Fe; AcOH / 1 h / 90 - 110 °C

3: tetrahydrofuran / 20 °C

With sulfuric acid; nitric acid; iron; acetic acid; In tetrahydrofuran; 1: Nitration / 2: Reduction / 3: Acylation;
DOI:10.1021/jm9900063