(R)-P,P-diphenyl-N-(1-phenyl-2-(trimethylsilyl)buta-2,3-dien-1-yl)phosphinic amide

Base Information

Chemical Name:(R)-P,P-diphenyl-N-(1-phenyl-2-(trimethylsilyl)buta-2,3-dien-1-yl)phosphinic amide
CAS No.:1566556-27-1
Molecular Formula:C₂₅H₂₈NOPSi
Molecular Weight:417.563
Hs Code.:

Synonyms:(R)-P,P-diphenyl-N-(1-phenyl-2-(trimethylsilyl)buta-2,3-dien-1-yl)phosphinic amide

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Chemical Property of (R)-P,P-diphenyl-N-(1-phenyl-2-(trimethylsilyl)buta-2,3-dien-1-yl)phosphinic amide

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Technology Process of (R)-P,P-diphenyl-N-(1-phenyl-2-(trimethylsilyl)buta-2,3-dien-1-yl)phosphinic amide

There total 2 articles about (R)-P,P-diphenyl-N-(1-phenyl-2-(trimethylsilyl)buta-2,3-dien-1-yl)phosphinic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 129217-85-2
trimethyl (3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)prop-1-yn-1-yl)silane

: 98837-46-8,67764-52-7
P,P-diphenyl-N-(phenylmethylene)phosphinic amide

: 1566556-27-1
(R)-P,P-diphenyl-N-(1-phenyl-2-(trimethylsilyl)buta-2,3-dien-1-yl)phosphinic amide

Guidance literature:: With BF₄^(1-)*C₄₀H₄₁N₂⁽¹⁺⁾; isopropyl alcohol; copper(l) chloride; sodium t-butanolate; In tetrahydrofuran; at -30 - 22 ℃; for 0.166667h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja500373s

Reference yield:

: 6224-91-5
trimethyl(prop-1-ynyl)silane

: 1566556-27-1
(R)-P,P-diphenyl-N-(1-phenyl-2-(trimethylsilyl)buta-2,3-dien-1-yl)phosphinic amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -25 °C / Inert atmosphere; Cooling with acetone-dry ice

1.2: 2 h / -25 - -20 °C / Inert atmosphere; Cooling with acetone-dry ice

1.3: 2 h / -20 - 22 °C / Inert atmosphere; Cooling with acetone-dry ice

2.1: isopropyl alcohol; BF₄^(1-)*C₄₀H₄₁N₂⁽¹⁺⁾; sodium t-butanolate; copper(l) chloride / tetrahydrofuran / 0.17 h / -30 - 22 °C / Inert atmosphere

With n-butyllithium; BF₄^(1-)*C₄₀H₄₁N₂⁽¹⁺⁾; isopropyl alcohol; copper(l) chloride; sodium t-butanolate; In tetrahydrofuran; hexane;
DOI:10.1021/ja500373s