6-{(S)-1-[(3R,4S)-4-(3,4-Difluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-nicotinonitrile

Base Information

Chemical Name:6-{(S)-1-[(3R,4S)-4-(3,4-Difluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-nicotinonitrile
CAS No.:1115961-94-8
Molecular Formula:C₁₈H₁₇F₂N₃O
Molecular Weight:329.349
Hs Code.:

Synonyms:6-{(S)-1-[(3R,4S)-4-(3,4-Difluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-nicotinonitrile

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Chemical Property of 6-{(S)-1-[(3R,4S)-4-(3,4-Difluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-nicotinonitrile

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Technology Process of 6-{(S)-1-[(3R,4S)-4-(3,4-Difluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-nicotinonitrile

There total 5 articles about 6-{(S)-1-[(3R,4S)-4-(3,4-Difluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1115961-96-0
6-{(S)-1-[(3R,4S)-1-benzyl-4-(3,4-difluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-nicotinonitrile

: 1115961-94-8
6-{(S)-1-[(3R,4S)-4-(3,4-Difluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-nicotinonitrile

Guidance literature:: With carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine; In toluene; at 100 ℃; for 1h;

Reference yield:

: 33252-28-7
6-chloronicotinonitrile

: 1115961-88-0
(S)-1-[(3R,4S)-1-benzyl-4-(3,4-difluoro-phenyl)-pyrrolidin-3-yl]-ethanol

: 1115961-94-8
6-{(S)-1-[(3R,4S)-4-(3,4-Difluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-nicotinonitrile

Guidance literature:: With NaH; In N,N-dimethyl-formamide;

Reference yield:

: 1115961-72-2
1-(1-benzyl-2,5-dihydro-1H-pyrrol-3-yl)-ethanone

: 1115961-94-8
6-{(S)-1-[(3R,4S)-4-(3,4-Difluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-nicotinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: rhodium(acac)bis ethylene; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / water; methanol / 8 h / 55 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.83 h / 20 - 50 °C

3.2: 3 h / 50 °C

4.1: N-ethyl-N,N-diisopropylamine; 2-Chloroethyl chloroformate / toluene / 1 h / 100 °C

4.2: 0.5 h / 85 °C

With lithium aluminium tetrahydride; sodium hydride; 2-Chloroethyl chloroformate; N-ethyl-N,N-diisopropylamine; rhodium(acac)bis ethylene; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;