(E)-3-(4-(dimethylamino)benzylidene)-6-nitro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one

Base Information

• Chemical Name: (E)-3-(4-(dimethylamino)benzylidene)-6-nitro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
• CAS No.: 1337863-20-3
• Molecular Formula: C₂₀H₁₈N₄O₃
• Molecular Weight: 362.388

Synonyms:(E)-3-(4-(dimethylamino)benzylidene)-6-nitro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one

Chemical Property of (E)-3-(4-(dimethylamino)benzylidene)-6-nitro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one

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Technology Process of (E)-3-(4-(dimethylamino)benzylidene)-6-nitro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one

There total 2 articles about (E)-3-(4-(dimethylamino)benzylidene)-6-nitro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Nitroanthranilic acid (619-17-0) → (E)-3-(4-(dimethylamino)benzylidene)-6-nitro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one (1337863-20-3)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / toluene / Reflux

2: sodium acetate; acetic acid / 8 h / Reflux

With sodium acetate; acetic acid; trichlorophosphate; In toluene;

DOI:10.1039/c1ob05884c

Reference yield:

4-dimethylamino-benzaldehyde (100-10-7) + 6-nitro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one (55727-50-9) → (E)-3-(4-(dimethylamino)benzylidene)-6-nitro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one (1337863-20-3)

Guidance literature:

With sodium acetate; acetic acid; for 8h; Reflux;

DOI:10.1039/c1ob05884c

Reference yield: 92.0%

(E)-3-(4-(dimethylamino)benzylidene)-6-nitro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one (1337863-20-3) → (E)-6-amino-3-(4-(dimethylamino)benzylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one (1337863-27-0)

Guidance literature:

With sodiumsulfide nonahydrate; sodium hydroxide; In ethanol; water; for 6h; Reflux;

DOI:10.1039/c1ob05884c

upstream raw materials:

4-dimethylamino-benzaldehyde

6-nitro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one

4-Nitroanthranilic acid

Downstream raw materials:

(E)-6-amino-3-(4-(dimethylamino)benzylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one

(E)-N-(3-(4-(dimethylamino)benzylidene)-9-oxo-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-6-yl)-3-(pyrrolidin-1-yl)propanamide

(E)-N-(3-(4-(dimethylamino)benzylidene)-9-oxo-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-6-yl)-3-(piperidin-1-yl)propanamide

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