2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

Base Information

Chemical Name:2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid
CAS No.:1080521-11-4
Molecular Formula:C₂₄H₁₇Cl₂N₃O₆S
Molecular Weight:546.387
Hs Code.:

Synonyms:2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

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Chemical Property of 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

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Technology Process of 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

There total 8 articles about 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1080522-19-5
methyl 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

: 1080521-11-4
2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2014.04.092

Reference yield:

: 1080522-10-6
5-(4-(carboxymethyl)-2-methoxyphenoxy)-4-nitro-1H-indole-2-carboxylic acid

: 1080521-11-4
2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: chloro-trimethyl-silane / 20 °C

2: ammonium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / 20 °C

3: hydrogen; palladium on activated charcoal / ethyl acetate

4: pyridine / dichloromethane / 20 °C

5: trichlorophosphate / dichloromethane / 60 °C

6: lithium hydroxide; water / tetrahydrofuran / 20 °C

With 4-methyl-morpholine; pyridine; ammonium hydroxide; chloro-trimethyl-silane; palladium on activated charcoal; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2014.04.092

Reference yield:

: 1080522-13-9
methyl 2-(4-(2-carbamoyl-4-nitro-1H-indol-5-yloxy)-3 methoxyphenyl)acetate

: 1080521-11-4
2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; palladium on activated charcoal / ethyl acetate

2: pyridine / dichloromethane / 20 °C

3: trichlorophosphate / dichloromethane / 60 °C

4: lithium hydroxide; water / tetrahydrofuran / 20 °C

With pyridine; palladium on activated charcoal; water; hydrogen; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2014.04.092