methyl 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

Base Information

Chemical Name:methyl 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate
CAS No.:1080522-19-5
Molecular Formula:C₂₅H₁₉Cl₂N₃O₆S
Molecular Weight:560.414
Hs Code.:

Synonyms:methyl 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

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Chemical Property of methyl 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

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Technology Process of methyl 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

There total 6 articles about methyl 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1080522-18-4
C₂₅H₂₁Cl₂N₃O₇S

: 1080522-19-5
methyl 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

Guidance literature:: With trichlorophosphate; In dichloromethane; at 60 ℃;
DOI:10.1016/j.bmcl.2014.04.092

Reference yield:

: 1080522-09-3
ethyl 5-(4-(2-ethoxy-2-oxoethyl)-2-methoxyphenoxy)-4-nitro-1H-indole-2-carboxylate

: 1080522-19-5
methyl 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hydroxide; water / tetrahydrofuran / 20 °C

2: chloro-trimethyl-silane / 20 °C

3: ammonium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / 20 °C

4: hydrogen; palladium on activated charcoal / ethyl acetate

5: pyridine / dichloromethane / 20 °C

6: trichlorophosphate / dichloromethane / 60 °C

With 4-methyl-morpholine; pyridine; ammonium hydroxide; chloro-trimethyl-silane; palladium on activated charcoal; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2014.04.092

Reference yield:

: 1080522-10-6
5-(4-(carboxymethyl)-2-methoxyphenoxy)-4-nitro-1H-indole-2-carboxylic acid

: 1080522-19-5
methyl 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: chloro-trimethyl-silane / 20 °C

2: ammonium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / 20 °C

3: hydrogen; palladium on activated charcoal / ethyl acetate

4: pyridine / dichloromethane / 20 °C

5: trichlorophosphate / dichloromethane / 60 °C

With 4-methyl-morpholine; pyridine; ammonium hydroxide; chloro-trimethyl-silane; palladium on activated charcoal; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2014.04.092