Technology Process of 3-cyano-3-{2-methoxy-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid
There total 10 articles about 3-cyano-3-{2-methoxy-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 3-cyano-3-{2-methoxy-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate;
With
water; sodium hydroxide;
In
tetrahydrofuran; methanol;
at 0 ℃;
for 30h;
With
citric acid;
In
water;
at 20 ℃;
pH=6;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium carbonate / acetonitrile / 16 h / 0 - 20 °C
2.1: piperidine; acetic acid / toluene / 5 h / 125 °C
3.1: methanol / 2 h / 70 °C
4.1: methanesulfonic acid / 2 h / 65 °C
5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 20 °C
6.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene; methanol / 4 h / 0 - 20 °C
7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 30 h / 0 °C
7.2: 20 °C / pH 6
With
piperidine; methanesulfonic acid; tributylphosphine; water; hydrogen; potassium carbonate; acetic acid; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethyl acetate; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / acetonitrile / 3 h / 20 °C
2.1: potassium carbonate / acetonitrile / 16 h / 0 - 20 °C
3.1: piperidine; acetic acid / toluene / 5 h / 125 °C
4.1: methanol / 2 h / 70 °C
5.1: methanesulfonic acid / 2 h / 65 °C
6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 20 °C
7.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene; methanol / 4 h / 0 - 20 °C
8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 30 h / 0 °C
8.2: 20 °C / pH 6
With
piperidine; methanesulfonic acid; tributylphosphine; water; hydrogen; potassium carbonate; acetic acid; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethyl acetate; toluene; acetonitrile;