4-(2-Benzyloxycarbamoyl-ethyl)-heptanedioic acid bis-(benzyloxy-amide)

Base Information

• Chemical Name: 4-(2-Benzyloxycarbamoyl-ethyl)-heptanedioic acid bis-(benzyloxy-amide)
• CAS No.: 141621-28-5
• Molecular Formula: C₃₁H₃₇N₃O₆
• Molecular Weight: 547.651
• Mol file: 141621-28-5.mol

Synonyms:4-(2-Benzyloxycarbamoyl-ethyl)-heptanedioic acid bis-(benzyloxy-amide)

Chemical Property of 4-(2-Benzyloxycarbamoyl-ethyl)-heptanedioic acid bis-(benzyloxy-amide)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-Benzyloxycarbamoyl-ethyl)-heptanedioic acid bis-(benzyloxy-amide)

There total 3 articles about 4-(2-Benzyloxycarbamoyl-ethyl)-heptanedioic acid bis-(benzyloxy-amide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-(2-carboxy-ethyl)-heptanedioic acid (5617-47-0) + O-benzylhydoxylamine hydrochloride (2687-43-6) → 4-(2-Benzyloxycarbamoyl-ethyl)-heptanedioic acid bis-(benzyloxy-amide) (141621-28-5)

Guidance literature:

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; water; Ambient temperature; pH ca. 4.8;

DOI:10.1016/S0040-4039(00)74153-0

Reference yield:

tris(2-cyanoethyl)nitromethane (1466-48-4) → 4-(2-Benzyloxycarbamoyl-ethyl)-heptanedioic acid bis-(benzyloxy-amide) (141621-28-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / nBu₃SnH, AIBN / acetonitrile / 1 h / Heating

2: 88 percent / conc. HCl / Heating

3: 88 percent / 1-ethyl-3-(dimethylaminopropyl)carbodiimide / tetrahydrofuran; H₂O / Ambient temperature; pH ca. 4.8

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; water; acetonitrile;

DOI:10.1016/S0040-4039(00)74153-0

Reference yield:

1,5-dicyano-3-(2-cyanoethyl)pentane (61582-70-5) → 4-(2-Benzyloxycarbamoyl-ethyl)-heptanedioic acid bis-(benzyloxy-amide) (141621-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / conc. HCl / Heating

2: 88 percent / 1-ethyl-3-(dimethylaminopropyl)carbodiimide / tetrahydrofuran; H₂O / Ambient temperature; pH ca. 4.8

With hydrogenchloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; water;

DOI:10.1016/S0040-4039(00)74153-0

upstream raw materials:

4-(2-carboxy-ethyl)-heptanedioic acid

O-benzylhydoxylamine hydrochloride

1,5-dicyano-3-(2-cyanoethyl)pentane

tris(2-cyanoethyl)nitromethane