naphthalene-2-sulfonic acid {3-[hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenyl}-methyl-amide

Base Information

• Chemical Name: naphthalene-2-sulfonic acid {3-[hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenyl}-methyl-amide
• CAS No.: 358673-08-2
• Molecular Formula: C₃₂H₂₉NO₅S
• Molecular Weight: 539.652
• Mol file: 358673-08-2.mol

Synonyms:naphthalene-2-sulfonic acid {3-[hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenyl}-methyl-amide

Chemical Property of naphthalene-2-sulfonic acid {3-[hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenyl}-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of naphthalene-2-sulfonic acid {3-[hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenyl}-methyl-amide

There total 4 articles about naphthalene-2-sulfonic acid {3-[hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenyl}-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-bromo-4-methoxy-benzene (104-92-7) + 3-[methyl-(naphthalene-2-sulfonyl)-amino]-benzoic acid ethyl ester (358673-06-0) → naphthalene-2-sulfonic acid {3-[hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenyl}-methyl-amide (358673-08-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃;

DOI:10.1021/jo001775t

Reference yield:

3-aminobenzoic acid ethyl ester (582-33-2) → naphthalene-2-sulfonic acid {3-[hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenyl}-methyl-amide (358673-08-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / DMAP / pyridine / 18 h / 75 °C

2: 75 percent / NaOH / ethanol / 22 h / 60 °C

3: 94 percent / n-BuLi / hexane; tetrahydrofuran / -78 - 0 °C

With dmap; sodium hydroxide; n-butyllithium; In tetrahydrofuran; pyridine; ethanol; hexane;

DOI:10.1021/jo001775t

Reference yield:

2-Naphthalenesulfonyl chloride (93-11-8) → naphthalene-2-sulfonic acid {3-[hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenyl}-methyl-amide (358673-08-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / DMAP / pyridine / 18 h / 75 °C

2: 75 percent / NaOH / ethanol / 22 h / 60 °C

3: 94 percent / n-BuLi / hexane; tetrahydrofuran / -78 - 0 °C

With dmap; sodium hydroxide; n-butyllithium; In tetrahydrofuran; pyridine; ethanol; hexane;

DOI:10.1021/jo001775t

upstream raw materials:

1-bromo-4-methoxy-benzene

3-[methyl-(naphthalene-2-sulfonyl)-amino]-benzoic acid ethyl ester

3-aminobenzoic acid ethyl ester

2-Naphthalenesulfonyl chloride

Downstream raw materials:

N-{2-methoxy-5-[1,6,6-tris-(3-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-4-methoxy-phenyl)-1,6-bis-(3-methylamino-phenyl)-hexa-2,4-diynyl]-benzyl}-N,N',N'-trimethyl-ethane-1,2-diamine

C₇₂H₅₆N₂O₁₂S₂

2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide

C₆₈H₅₆N₂O₈S₂