3-[methyl-(naphthalene-2-sulfonyl)-amino]-benzoic acid ethyl ester

Base Information

• Chemical Name: 3-[methyl-(naphthalene-2-sulfonyl)-amino]-benzoic acid ethyl ester
• CAS No.: 358673-06-0
• Molecular Formula: C₂₀H₁₉NO₄S
• Molecular Weight: 369.441
• Mol file: 358673-06-0.mol

Synonyms:3-[methyl-(naphthalene-2-sulfonyl)-amino]-benzoic acid ethyl ester

Chemical Property of 3-[methyl-(naphthalene-2-sulfonyl)-amino]-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[methyl-(naphthalene-2-sulfonyl)-amino]-benzoic acid ethyl ester

There total 3 articles about 3-[methyl-(naphthalene-2-sulfonyl)-amino]-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl N-(2-naphthalenesulfonyl)-3-aminobenzoate (209173-75-1) + methyl iodide (74-88-4) → 3-[methyl-(naphthalene-2-sulfonyl)-amino]-benzoic acid ethyl ester (358673-06-0)

Guidance literature:

With sodium hydroxide; In ethanol; at 60 ℃; for 22h;

DOI:10.1021/jo001775t

Reference yield:

3-aminobenzoic acid ethyl ester (582-33-2) → 3-[methyl-(naphthalene-2-sulfonyl)-amino]-benzoic acid ethyl ester (358673-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / DMAP / pyridine / 18 h / 75 °C

2: 75 percent / NaOH / ethanol / 22 h / 60 °C

With dmap; sodium hydroxide; In pyridine; ethanol;

DOI:10.1021/jo001775t

Reference yield:

2-Naphthalenesulfonyl chloride (93-11-8) → 3-[methyl-(naphthalene-2-sulfonyl)-amino]-benzoic acid ethyl ester (358673-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / DMAP / pyridine / 18 h / 75 °C

2: 75 percent / NaOH / ethanol / 22 h / 60 °C

With dmap; sodium hydroxide; In pyridine; ethanol;

DOI:10.1021/jo001775t

upstream raw materials:

ethyl N-(2-naphthalenesulfonyl)-3-aminobenzoate

methyl iodide

3-aminobenzoic acid ethyl ester

2-Naphthalenesulfonyl chloride

Downstream raw materials:

N-{2-methoxy-5-[1,6,6-tris-(3-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-4-methoxy-phenyl)-1,6-bis-(3-methylamino-phenyl)-hexa-2,4-diynyl]-benzyl}-N,N',N'-trimethyl-ethane-1,2-diamine

C₇₂H₅₆N₂O₁₂S₂

2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide

C₆₈H₅₆N₂O₈S₂