3-[4-[2-(2,5-Dichloro-4-nitrophenyl)ethyl]-1-piperazinyl]-1,2-benzisothiazole

Base Information

• Chemical Name: 3-[4-[2-(2,5-Dichloro-4-nitrophenyl)ethyl]-1-piperazinyl]-1,2-benzisothiazole
• CAS No.: 160384-38-3
• Molecular Formula: C₁₉H₁₈Cl₂N₄O₂S
• Molecular Weight: 437.35
• Mol file: 160384-38-3.mol

Synonyms:2,5-Dichloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl)-nitrobenzene

Chemical Property of 3-[4-[2-(2,5-Dichloro-4-nitrophenyl)ethyl]-1-piperazinyl]-1,2-benzisothiazole

Chemical Property:

• Solubility.: Dichloromethane, Methanol

Purity/Quality:

3-[4-[2-(2,5-Dichloro-4-nitrophenyl)ethyl]-1-piperazinyl]-1,2-benzisothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-[2-(2,5-Dichloro-4-nitrophenyl)ethyl]-1-piperazinyl]-1,2-benzisothiazole

There total 4 articles about 3-[4-[2-(2,5-Dichloro-4-nitrophenyl)ethyl]-1-piperazinyl]-1,2-benzisothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2,5-Dichloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethenyl)-nitrobenzene (160384-37-2) → 2,5-Dichloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl)-nitrobenzene (160384-38-3)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane;

DOI:10.1080/00397919608003533

Reference yield: 71.0%

→ 2,5-Dichloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl)-nitrobenzene (160384-38-3)

Guidance literature:

Reference yield:

2,5-dichlorotoluene (19398-61-9) → 2,5-Dichloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl)-nitrobenzene (160384-38-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 56 percent / conc. H₂SO₄, HNO₃ / acetic acid / 2 h / Ambient temperature

2: 58 percent / tetrahydrofuran / 8 h / Heating

3: 93 percent / acetic acid / Ambient temperature

4: 71 percent / acetic acid, sodium triacetoxyborohydride / 1,2-dichloro-ethane

With sulfuric acid; nitric acid; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; acetic acid; 1,2-dichloro-ethane;

DOI:10.1080/00397919608003533

upstream raw materials:

2,5-Dichloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethenyl)-nitrobenzene

2,5-dichlorotoluene

Downstream raw materials:

methyl (5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-4-chloro-2-nitrophenyl)-cyanoacetate

5-Chloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl)-2-(bis-(methoxycarbonyl)methyl)-nitrobenzene

methyl 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-4-chloro-2-nitrophenyl acetate

5-(2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl)-4-chloro-2-nitrophenyl acetic acid