5,5-dimethyl-2-(2,2,3,3,3-pentafluoropropanoyl)-3-phenylaminocyclohex-2-en-1-one

Base Information

• Chemical Name: 5,5-dimethyl-2-(2,2,3,3,3-pentafluoropropanoyl)-3-phenylaminocyclohex-2-en-1-one
• CAS No.: 1202752-69-9
• Molecular Formula: C₁₇H₁₆F₅NO₂
• Molecular Weight: 361.312
• Mol file: 1202752-69-9.mol

Synonyms:5,5-dimethyl-2-(2,2,3,3,3-pentafluoropropanoyl)-3-phenylaminocyclohex-2-en-1-one

Chemical Property of 5,5-dimethyl-2-(2,2,3,3,3-pentafluoropropanoyl)-3-phenylaminocyclohex-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,5-dimethyl-2-(2,2,3,3,3-pentafluoropropanoyl)-3-phenylaminocyclohex-2-en-1-one

There total 2 articles about 5,5-dimethyl-2-(2,2,3,3,3-pentafluoropropanoyl)-3-phenylaminocyclohex-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-chloro-5,5-dimethyl-2-(2,2,3,3,3-pentafluoropropanoyl)cyclohex-2-en-1-one (1202752-63-3) + aniline (62-53-3) → 5,5-dimethyl-2-(2,2,3,3,3-pentafluoropropanoyl)-3-phenylaminocyclohex-2-en-1-one (1202752-69-9)

Guidance literature:

In chloroform;

DOI:10.1134/S1070428009070033

Reference yield:

2-pentafluoropropionyl-5,5-dimethylcyclohexane-1,3-dione (950908-44-8) → 5,5-dimethyl-2-(2,2,3,3,3-pentafluoropropanoyl)-3-phenylaminocyclohex-2-en-1-one (1202752-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride

With oxalyl dichloride;

DOI:10.1134/S1070363211040098

Reference yield: 76.0%

5,5-dimethyl-2-(2,2,3,3,3-pentafluoropropanoyl)-3-phenylaminocyclohex-2-en-1-one (1202752-69-9) → 5,5-dimethyl-2-(2,2,3,3,3-pentafluoro-1-hydroxypropyl)-3-phenylaminocyclohex-2-en-1-one (1313409-37-8)

Guidance literature:

With triethylsilane; lithium perchlorate; In trifluoroacetic acid; at 20 ℃; for 5h; regioselective reaction;

DOI:10.1134/S1070363211040098

upstream raw materials:

3-chloro-5,5-dimethyl-2-(2,2,3,3,3-pentafluoropropanoyl)cyclohex-2-en-1-one

aniline

2-pentafluoropropionyl-5,5-dimethylcyclohexane-1,3-dione

Downstream raw materials:

5,5-dimethyl-2-(2,2,3,3,3-pentafluoro-1-hydroxypropyl)-3-phenylaminocyclohex-2-en-1-one