(Z)-benzyl (6-((tert-butyldimethylsilyl)oxy)-6-(2-oxooxazolidin-3-yl)hex-5-en-1-yl)(methyl)carbamate

Base Information

Chemical Name:(Z)-benzyl (6-((tert-butyldimethylsilyl)oxy)-6-(2-oxooxazolidin-3-yl)hex-5-en-1-yl)(methyl)carbamate
CAS No.:1330660-56-4
Molecular Formula:C₂₄H₃₈N₂O₅Si
Molecular Weight:462.662
Hs Code.:

Synonyms:(Z)-benzyl (6-((tert-butyldimethylsilyl)oxy)-6-(2-oxooxazolidin-3-yl)hex-5-en-1-yl)(methyl)carbamate

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Chemical Property of (Z)-benzyl (6-((tert-butyldimethylsilyl)oxy)-6-(2-oxooxazolidin-3-yl)hex-5-en-1-yl)(methyl)carbamate

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Technology Process of (Z)-benzyl (6-((tert-butyldimethylsilyl)oxy)-6-(2-oxooxazolidin-3-yl)hex-5-en-1-yl)(methyl)carbamate

There total 1 articles about (Z)-benzyl (6-((tert-butyldimethylsilyl)oxy)-6-(2-oxooxazolidin-3-yl)hex-5-en-1-yl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 947181-34-2
6-[[(benzyloxy)carbonyl](methyl)amino]caproic acid

: 1330660-56-4
(Z)-benzyl (6-((tert-butyldimethylsilyl)oxy)-6-(2-oxooxazolidin-3-yl)hex-5-en-1-yl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h / -10 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 4 h / 20 °C / Inert atmosphere

With dmap; n-butyllithium; diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja206050b

Reference yield: 93.0%

: 1330660-56-4
(Z)-benzyl (6-((tert-butyldimethylsilyl)oxy)-6-(2-oxooxazolidin-3-yl)hex-5-en-1-yl)(methyl)carbamate

: 58109-40-3
diphenyliodonium hexafluorophosphate

: 1330660-79-1
(S)-benzyl methyl(6-oxo-6-(2-oxooxazolidin-3-yl)-5-phenylhexyl)carbamate

Guidance literature:: With [((CH₃)2C(C₃H₃NOC₆H₅)2)Cu(OSO₂CF₃)]; CuOTf*1/2PhMe; In dichloromethane; toluene; at 5 ℃; for 24h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ja206050b